Effect of Carbohydrate Restriction in Patients with Hyperinsulinemic Hypoglycemia after Roux-en-Y Gastric Bypass

Background Hyperinsulinemic hypoglycemia is a rare complication of Roux-en-Y gastric bypass (RYGB) surgery. Meals with a high carbohydrate (carb) content and high glycemic index (GI) may provoke these hypoglycemic attacks. The aim of this study is to assess the effects of reducing meal carb content...

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Bibliographic Details
Published in:Obesity surgery 2014-11, Vol.24 (11), p.1850-1855
Main Authors: Botros, Nadia, Rijnaarts, Iris, Brandts, Hans, Bleumink, Gysele, Janssen, Ignace, de Boer, Hans
Format: Article
Language:English
Subjects:
Adult
Blood Glucose
Carbohydrates
Dietary Carbohydrates - administration & dosage
Female
Gastric Bypass - adverse effects
Gastric Bypass - methods
Gastrointestinal surgery
Glycemic index
Humans
Hypoglycemia
Hypoglycemia - blood
Hypoglycemia - diet therapy
Hypoglycemia - etiology
Insulin - blood
Male
Meals
Medicine
Medicine & Public Health
Middle Aged
Obesity
Obesity, Morbid - complications
Obesity, Morbid - surgery
Original Contributions
Surgery
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Summary:Background Hyperinsulinemic hypoglycemia is a rare complication of Roux-en-Y gastric bypass (RYGB) surgery. Meals with a high carbohydrate (carb) content and high glycemic index (GI) may provoke these hypoglycemic attacks. The aim of this study is to assess the effects of reducing meal carb content and GI on glycemic responses in patients with post-RYGB hypoglycemia. Methods Fourteen patients with post-RYGB hypoglycemia underwent two meal tests: a mixed meal test (MMT) with a carb content of 30 g and a meal test with the low GI supplement, Glucerna SR 1.5® (Glucerna meal test (GMT)). Plasma glucose and serum insulin levels were measured for a period of 6 h. Results Peak glucose levels were reached at T 30 during GMT and at T 60 during MMT, and they were 1.5 ± 0.3 mmol/L lower during GMT than during MMT (7.5 ± 0.4 vs 9.0 ± 0.4 mmol/L, P  
ISSN:0960-8923
1708-0428
DOI:10.1007/s11695-014-1319-6