Carbonic Anhydrase IX in the Prediction of Right Ventricular Dysfunction in Patients With Hemodynamically Stable Acute Pulmonary Embolism

Right ventricular dysfunction (RVD) defined by echocardiography and/or by natriuretic peptides is a well-known predictor of prognosis in patients with pulmonary embolism (PE). This study investigated carbonic anhydrase IX (CA IX) levels for predicting echocardiographic RVD in patients with PE. A tot...

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Published in:Clinical and applied thrombosis/hemostasis 2014-11, Vol.20 (8), p.838-843
Main Authors: Abul, Yasin, Ozsu, Savas, Mentese, Ahmet, Durmus, Ismet, Bektas, Hayriye, Pehlivanlar, Mehtap, Turan, Oguzhan Ekrem, Sumer, Aysegul, Orem, Asim, Ozlu, Tevfik
Format: Article
Language:English
Subjects:
Acute Disease
Adult
Aged
Antigens, Neoplasm - blood
Carbonic Anhydrase IX
Carbonic Anhydrases - blood
Echocardiography
Embolisms
Female
Health risk assessment
Hemodynamics
Humans
Logistic Models
Male
Middle Aged
Natriuretic Peptide, Brain - blood
Peptide Fragments - blood
Pulmonary Embolism - complications
Pulmonary Embolism - physiopathology
Pulmonary embolisms
Troponin T - blood
Ventricular Dysfunction, Right - blood
Ventricular Dysfunction, Right - enzymology
Ventricular Dysfunction, Right - etiology
Ventricular Dysfunction, Right - physiopathology
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Summary:Right ventricular dysfunction (RVD) defined by echocardiography and/or by natriuretic peptides is a well-known predictor of prognosis in patients with pulmonary embolism (PE). This study investigated carbonic anhydrase IX (CA IX) levels for predicting echocardiographic RVD in patients with PE. A total of 150 normotensive patients with PE were included. The levels of CA IX, N-terminal pro-brain-type natriuretic peptide (NT-proBNP), and high-sensitive cardiac troponin T were significantly elevated in patients with PE with RVD on echocardiography. A receiver–operating characteristic curve analysis showed a value of 0.751 for CA IX, 0.714 for NT-proBNP, and 0.650 for high-sensitive troponin-T to predict RVD on echocardiography. The cutoff value to predict RVD was 32.45 pg/mL for CA IX (sensitivity: 89.3% and specificity: 51.1%). There was a significant positive correlation between the CA IX level and the systolic pulmonary arterial pressure on echocardiography (ρ = .21; P = .035). The CA IX is a significant serologic predictor of RVD in acute PE and correlates with systolic pulmonary arterial pressure.
ISSN:1076-0296
1938-2723
DOI:10.1177/1076029613486540