Placental lesions of vascular insufficiency are associated with anti-angiogenic state in women with preeclampsia

Objective: To evaluate if placental histopathological changes of vascular insufficiency correlate with circulating angiogenic factors in patients with preeclampsia. Materials and methods: Subjects were selected from a previous prospective cohort study of preeclampsia based on the availability of pla...

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Bibliographic Details
Published in:Hypertension in pregnancy 2014-11, Vol.33 (4), p.427-439
Main Authors: Baltajian, Kedak, Hecht, Jonathan L., Wenger, Julia B., Salahuddin, Saira, Verlohren, Stefan, Perschel, Frank H., Zsengeller, Zsuzsanna K., Thadhani, Ravi, Karumanchi, S. Ananth, Rana, Sarosh
Format: Article
Language:English
Subjects:
Adult
Angiogenic factors
Cohort Studies
Female
Humans
Placenta
Placenta - pathology
Placenta Growth Factor
Placental Insufficiency - blood
Placental Insufficiency - pathology
Placental lesions
Pre-Eclampsia - blood
Pre-Eclampsia - pathology
Pregnancy
Pregnancy Proteins - blood
Vascular Endothelial Growth Factor Receptor-1 - blood
Young Adult
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Summary:Objective: To evaluate if placental histopathological changes of vascular insufficiency correlate with circulating angiogenic factors in patients with preeclampsia. Materials and methods: Subjects were selected from a previous prospective cohort study of preeclampsia based on the availability of plasma anti-angiogenic factor (sFlt1) and pro-angiogenic factor (PlGF) measurements and placental histology specimens. Preeclamptic patients were divided into two groups based on plasma levels of these factors described as a ratio: anti-angiogenic preeclampsia with sFlt1/PlGF ratio 85 and normal angiogenic preeclampsia with sFlt1/PlGF 
ISSN:1064-1955
1525-6065
DOI:10.3109/10641955.2014.926914