Placental lesions of vascular insufficiency are associated with anti-angiogenic state in women with preeclampsia

Objective: To evaluate if placental histopathological changes of vascular insufficiency correlate with circulating angiogenic factors in patients with preeclampsia. Materials and methods: Subjects were selected from a previous prospective cohort study of preeclampsia based on the availability of pla...

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Published in:Hypertension in pregnancy 2014-11, Vol.33 (4), p.427-439
Main Authors: Baltajian, Kedak, Hecht, Jonathan L., Wenger, Julia B., Salahuddin, Saira, Verlohren, Stefan, Perschel, Frank H., Zsengeller, Zsuzsanna K., Thadhani, Ravi, Karumanchi, S. Ananth, Rana, Sarosh
Format: Article
Language:English
Subjects:
Adult
Angiogenic factors
Cohort Studies
Female
Humans
Placenta
Placenta - pathology
Placenta Growth Factor
Placental Insufficiency - blood
Placental Insufficiency - pathology
Placental lesions
Pre-Eclampsia - blood
Pre-Eclampsia - pathology
Pregnancy
Pregnancy Proteins - blood
Vascular Endothelial Growth Factor Receptor-1 - blood
Young Adult
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cited_by cdi_FETCH-LOGICAL-c418t-fb65a44f01dfd72a81a5c1eb0c4cb023e1a0b72da85ede86b4f1ecdd6ec687873
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container_title Hypertension in pregnancy
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creator Baltajian, Kedak
Hecht, Jonathan L.
Wenger, Julia B.
Salahuddin, Saira
Verlohren, Stefan
Perschel, Frank H.
Zsengeller, Zsuzsanna K.
Thadhani, Ravi
Karumanchi, S. Ananth
Rana, Sarosh
description Objective: To evaluate if placental histopathological changes of vascular insufficiency correlate with circulating angiogenic factors in patients with preeclampsia. Materials and methods: Subjects were selected from a previous prospective cohort study of preeclampsia based on the availability of plasma anti-angiogenic factor (sFlt1) and pro-angiogenic factor (PlGF) measurements and placental histology specimens. Preeclamptic patients were divided into two groups based on plasma levels of these factors described as a ratio: anti-angiogenic preeclampsia with sFlt1/PlGF ratio 85 and normal angiogenic preeclampsia with sFlt1/PlGF 
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Ananth ; Rana, Sarosh</creator><creatorcontrib>Baltajian, Kedak ; Hecht, Jonathan L. ; Wenger, Julia B. ; Salahuddin, Saira ; Verlohren, Stefan ; Perschel, Frank H. ; Zsengeller, Zsuzsanna K. ; Thadhani, Ravi ; Karumanchi, S. Ananth ; Rana, Sarosh</creatorcontrib><description>Objective: To evaluate if placental histopathological changes of vascular insufficiency correlate with circulating angiogenic factors in patients with preeclampsia. Materials and methods: Subjects were selected from a previous prospective cohort study of preeclampsia based on the availability of plasma anti-angiogenic factor (sFlt1) and pro-angiogenic factor (PlGF) measurements and placental histology specimens. Preeclamptic patients were divided into two groups based on plasma levels of these factors described as a ratio: anti-angiogenic preeclampsia with sFlt1/PlGF ratio 85 and normal angiogenic preeclampsia with sFlt1/PlGF &lt; 85. The placental lesions of vascular insufficiency that were studied specifically included atherosis, infarcts, syncytial knots, acute and chronic abruption, hematoma, and fetal thrombosis. The data are shown as median (quartile 1 and quartile 3) or n (%) when appropriate. Results: The anti-angiogenic preeclampsia group (N = 48) presented at an earlier gestational age (weeks) than the normal angiogenic group (N = 28); {32 (28, 34) versus 35 (32, 36), p = 0.002}, had higher systolic blood pressure (mmHg) {154 (147, 168) versus 147 (132, 158), p = 0.02}, delivered early (weeks) {(32 (29, 34) versus 36 (34, 37), p &lt; 0.001} and had lower birth weight (grams) {(1550 (1055, 2060) versus 2655 (2285, 3343), p &lt; 0.001}. Several pathologic lesions were found significantly more often in the anti-angiogenic preeclampsia group; atherosis {27.7% versus 3.6%, p &lt; 0.05}, infarcts {58.3% versus 3.6%, p = 0.002}, and syncytial knots {81.3% versus 39.3%, p &lt; 0.001}. Conclusion: Preeclamptic patients with imbalance in circulating angiogenic factors have disproportionally higher rates of placental vascular lesions historically associated with severe disease.</description><identifier>ISSN: 1064-1955</identifier><identifier>EISSN: 1525-6065</identifier><identifier>DOI: 10.3109/10641955.2014.926914</identifier><identifier>PMID: 25062083</identifier><language>eng</language><publisher>England: Informa Healthcare USA, Inc</publisher><subject>Adult ; Angiogenic factors ; Cohort Studies ; Female ; Humans ; Placenta ; Placenta - pathology ; Placenta Growth Factor ; Placental Insufficiency - blood ; Placental Insufficiency - pathology ; Placental lesions ; Pre-Eclampsia - blood ; Pre-Eclampsia - pathology ; Pregnancy ; Pregnancy Proteins - blood ; Vascular Endothelial Growth Factor Receptor-1 - blood ; Young Adult</subject><ispartof>Hypertension in pregnancy, 2014-11, Vol.33 (4), p.427-439</ispartof><rights>2014 Informa Healthcare USA, Inc. All rights reserved: reproduction in whole or part not permitted 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-fb65a44f01dfd72a81a5c1eb0c4cb023e1a0b72da85ede86b4f1ecdd6ec687873</citedby><cites>FETCH-LOGICAL-c418t-fb65a44f01dfd72a81a5c1eb0c4cb023e1a0b72da85ede86b4f1ecdd6ec687873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25062083$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baltajian, Kedak</creatorcontrib><creatorcontrib>Hecht, Jonathan L.</creatorcontrib><creatorcontrib>Wenger, Julia B.</creatorcontrib><creatorcontrib>Salahuddin, Saira</creatorcontrib><creatorcontrib>Verlohren, Stefan</creatorcontrib><creatorcontrib>Perschel, Frank H.</creatorcontrib><creatorcontrib>Zsengeller, Zsuzsanna K.</creatorcontrib><creatorcontrib>Thadhani, Ravi</creatorcontrib><creatorcontrib>Karumanchi, S. Ananth</creatorcontrib><creatorcontrib>Rana, Sarosh</creatorcontrib><title>Placental lesions of vascular insufficiency are associated with anti-angiogenic state in women with preeclampsia</title><title>Hypertension in pregnancy</title><addtitle>Hypertens Pregnancy</addtitle><description>Objective: To evaluate if placental histopathological changes of vascular insufficiency correlate with circulating angiogenic factors in patients with preeclampsia. Materials and methods: Subjects were selected from a previous prospective cohort study of preeclampsia based on the availability of plasma anti-angiogenic factor (sFlt1) and pro-angiogenic factor (PlGF) measurements and placental histology specimens. Preeclamptic patients were divided into two groups based on plasma levels of these factors described as a ratio: anti-angiogenic preeclampsia with sFlt1/PlGF ratio 85 and normal angiogenic preeclampsia with sFlt1/PlGF &lt; 85. The placental lesions of vascular insufficiency that were studied specifically included atherosis, infarcts, syncytial knots, acute and chronic abruption, hematoma, and fetal thrombosis. The data are shown as median (quartile 1 and quartile 3) or n (%) when appropriate. Results: The anti-angiogenic preeclampsia group (N = 48) presented at an earlier gestational age (weeks) than the normal angiogenic group (N = 28); {32 (28, 34) versus 35 (32, 36), p = 0.002}, had higher systolic blood pressure (mmHg) {154 (147, 168) versus 147 (132, 158), p = 0.02}, delivered early (weeks) {(32 (29, 34) versus 36 (34, 37), p &lt; 0.001} and had lower birth weight (grams) {(1550 (1055, 2060) versus 2655 (2285, 3343), p &lt; 0.001}. Several pathologic lesions were found significantly more often in the anti-angiogenic preeclampsia group; atherosis {27.7% versus 3.6%, p &lt; 0.05}, infarcts {58.3% versus 3.6%, p = 0.002}, and syncytial knots {81.3% versus 39.3%, p &lt; 0.001}. Conclusion: Preeclamptic patients with imbalance in circulating angiogenic factors have disproportionally higher rates of placental vascular lesions historically associated with severe disease.</description><subject>Adult</subject><subject>Angiogenic factors</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Placenta</subject><subject>Placenta - pathology</subject><subject>Placenta Growth Factor</subject><subject>Placental Insufficiency - blood</subject><subject>Placental Insufficiency - pathology</subject><subject>Placental lesions</subject><subject>Pre-Eclampsia - blood</subject><subject>Pre-Eclampsia - pathology</subject><subject>Pregnancy</subject><subject>Pregnancy Proteins - blood</subject><subject>Vascular Endothelial Growth Factor Receptor-1 - blood</subject><subject>Young Adult</subject><issn>1064-1955</issn><issn>1525-6065</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp9kcFu1DAURSNERUvhDxDykk0GO7GdzAaEqhaQKtEFrK0X-7njyrGD7TCavydRWiQ2XdmSz73v6biq3jG6axndf2RUcrYXYtdQxnf7Ru4Zf1FdMNGIWlIpXi73BalX5rx6nfMDpazjXLyqzhtBZUP79qKa7jxoDAU88ZhdDJlES_5A1rOHRFzIs7VOOwz6RCAhgZyjdlDQkKMrBwKhuBrCvYv3GJwmuSxvS44c44hhY6aEqD2MU3bwpjqz4DO-fTwvq1831z-vvtW3P75-v_pyW2vO-lLbQQrg3FJmrOka6BkIzXCgmuuBNi0yoEPXGOgFGuzlwC1DbYxELfuu79rL6sPWO6X4e8Zc1OiyRu8hYJyzYpLRTrayXVG-oTrFnBNaNSU3QjopRtXqWj25VqtrtbleYu8fJ8zDiOZf6EnuAnzeABdsTCMcY_JGFTj5mGyCoF1e658d8em_hgOCLwe9_IN6iHMKi8Dnd_wLkVakVA</recordid><startdate>201411</startdate><enddate>201411</enddate><creator>Baltajian, Kedak</creator><creator>Hecht, Jonathan L.</creator><creator>Wenger, Julia B.</creator><creator>Salahuddin, Saira</creator><creator>Verlohren, Stefan</creator><creator>Perschel, Frank H.</creator><creator>Zsengeller, Zsuzsanna K.</creator><creator>Thadhani, Ravi</creator><creator>Karumanchi, S. 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Ananth</creatorcontrib><creatorcontrib>Rana, Sarosh</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension in pregnancy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baltajian, Kedak</au><au>Hecht, Jonathan L.</au><au>Wenger, Julia B.</au><au>Salahuddin, Saira</au><au>Verlohren, Stefan</au><au>Perschel, Frank H.</au><au>Zsengeller, Zsuzsanna K.</au><au>Thadhani, Ravi</au><au>Karumanchi, S. Ananth</au><au>Rana, Sarosh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Placental lesions of vascular insufficiency are associated with anti-angiogenic state in women with preeclampsia</atitle><jtitle>Hypertension in pregnancy</jtitle><addtitle>Hypertens Pregnancy</addtitle><date>2014-11</date><risdate>2014</risdate><volume>33</volume><issue>4</issue><spage>427</spage><epage>439</epage><pages>427-439</pages><issn>1064-1955</issn><eissn>1525-6065</eissn><abstract>Objective: To evaluate if placental histopathological changes of vascular insufficiency correlate with circulating angiogenic factors in patients with preeclampsia. Materials and methods: Subjects were selected from a previous prospective cohort study of preeclampsia based on the availability of plasma anti-angiogenic factor (sFlt1) and pro-angiogenic factor (PlGF) measurements and placental histology specimens. Preeclamptic patients were divided into two groups based on plasma levels of these factors described as a ratio: anti-angiogenic preeclampsia with sFlt1/PlGF ratio 85 and normal angiogenic preeclampsia with sFlt1/PlGF &lt; 85. The placental lesions of vascular insufficiency that were studied specifically included atherosis, infarcts, syncytial knots, acute and chronic abruption, hematoma, and fetal thrombosis. The data are shown as median (quartile 1 and quartile 3) or n (%) when appropriate. Results: The anti-angiogenic preeclampsia group (N = 48) presented at an earlier gestational age (weeks) than the normal angiogenic group (N = 28); {32 (28, 34) versus 35 (32, 36), p = 0.002}, had higher systolic blood pressure (mmHg) {154 (147, 168) versus 147 (132, 158), p = 0.02}, delivered early (weeks) {(32 (29, 34) versus 36 (34, 37), p &lt; 0.001} and had lower birth weight (grams) {(1550 (1055, 2060) versus 2655 (2285, 3343), p &lt; 0.001}. Several pathologic lesions were found significantly more often in the anti-angiogenic preeclampsia group; atherosis {27.7% versus 3.6%, p &lt; 0.05}, infarcts {58.3% versus 3.6%, p = 0.002}, and syncytial knots {81.3% versus 39.3%, p &lt; 0.001}. Conclusion: Preeclamptic patients with imbalance in circulating angiogenic factors have disproportionally higher rates of placental vascular lesions historically associated with severe disease.</abstract><cop>England</cop><pub>Informa Healthcare USA, Inc</pub><pmid>25062083</pmid><doi>10.3109/10641955.2014.926914</doi><tpages>13</tpages></addata></record>
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ispartof Hypertension in pregnancy, 2014-11, Vol.33 (4), p.427-439
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source Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list)
subjects Adult
Angiogenic factors
Cohort Studies
Female
Humans
Placenta
Placenta - pathology
Placenta Growth Factor
Placental Insufficiency - blood
Placental Insufficiency - pathology
Placental lesions
Pre-Eclampsia - blood
Pre-Eclampsia - pathology
Pregnancy
Pregnancy Proteins - blood
Vascular Endothelial Growth Factor Receptor-1 - blood
Young Adult
title Placental lesions of vascular insufficiency are associated with anti-angiogenic state in women with preeclampsia
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