DELAYED EXCITATORY REACTION FOLLOWING INTERACTION OF COCAINE AND MONOAMINE OXIDASE INHIBITOR (PHENELZINE)

A case report is presented in which a patient receiving the monoamine oxidase inhibitor, phenelzine, developed a delayed excitatory reaction following administration of topical cocaine spray during anaesthesia for vocal cordsurgery. The pharmacological basis of the drug interaction is discussed.

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1991-04, Vol.66 (4), p.516-518
Main Authors: TORDOFF, S.G., STUBBING, J.F., LINTER, S.P.K.
Format: Article
Language:English
Subjects:
Aged
Anaesthetics
Anesthesia, Local - adverse effects
Biological and medical sciences
Cocaine - adverse effects
Coma - chemically induced
Complications: drug interaction
Drug Interactions
Drug toxicity and drugs side effects treatment
Humans
local: cocaine
Male
Medical sciences
Miscellaneous (drug allergy, mutagens, teratogens...)
monamine oxidase inhibitors
monoamine oxidase inhibitors
Pharmacology. Drug treatments
Pharmacology: cocaine
Phenelzine - adverse effects
Serotonin - metabolism
Sympathetic Nervous System - drug effects
Sympathetic Nervous System - metabolism
Time Factors
Vocal Cords - surgery
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Description
Summary:A case report is presented in which a patient receiving the monoamine oxidase inhibitor, phenelzine, developed a delayed excitatory reaction following administration of topical cocaine spray during anaesthesia for vocal cordsurgery. The pharmacological basis of the drug interaction is discussed.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/66.4.516