Strategies in the Design of Small-Molecule Fluorescent Probes for Peptidases

Peptidases, which can cleave specific peptide bonds in innumerable categories of substrates, usually present pivotal positions in protein activation, cell signaling and regulation as well as in the origination of amino acids for protein generation or application in other metabolic pathways. They are...

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Bibliographic Details
Published in:Medicinal research reviews 2014-11, Vol.34 (6), p.1217-1241
Main Authors: Chen, Laizhong, Li, Jing, Du, Lupei, Li, Minyong
Format: Article
Language:English
Subjects:
design strategies
Drug Design
Fluorescent Dyes - chemistry
Humans
Molecular Probes - chemistry
Molecular Probes - pharmacology
peptidases
Peptide Hydrolases - drug effects
Peptide Hydrolases - metabolism
Protein Binding - drug effects
Signal Transduction
small-molecule fluorescent probes
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Summary:Peptidases, which can cleave specific peptide bonds in innumerable categories of substrates, usually present pivotal positions in protein activation, cell signaling and regulation as well as in the origination of amino acids for protein generation or application in other metabolic pathways. They are also involved in many pathological conditions, such as cancer, atherosclerosis, arthritis, and neurodegenerative disorders. This review article aims to conduct a wide‐ranging survey on the development of small‐molecule fluorescent probes for peptidases, as well as to realize the state of the art in the tailor‐made probes for diverse types of peptidases.
ISSN:0198-6325
1098-1128
DOI:10.1002/med.21316