Age-Related Differences in NMDA Receptor Subunits of Prenatally Methamphetamine-Exposed Male Rats

There is accumulating evidence that methamphetamine (MA) is a widely abused drug popular among pregnant women. MA exposure is associated with changes in the function of neurotransmitter systems, namely the dopaminergic, serotonergic and glutamatergic systems. Since N -methyl- d -aspartate receptors...

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Bibliographic Details
Published in:Neurochemical research 2014-11, Vol.39 (11), p.2040-2046
Main Authors: Vrajová, Monika, Schutová, Barbora, Klaschka, Jan, Štěpánková, Hana, Řípová, Daniela, Šlamberová, Romana
Format: Article
Language:English
Subjects:
Aging
Animals
Animals, Newborn
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Female
Hippocampus - drug effects
Hippocampus - metabolism
Male
Methamphetamine - toxicity
Neurochemistry
Neurology
Neurosciences
Original Paper
Pregnancy
Prenatal Exposure Delayed Effects - metabolism
Protein Subunits - metabolism
Rats, Sprague-Dawley
Receptors, N-Methyl-D-Aspartate - metabolism
Signal Transduction - drug effects
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Summary:There is accumulating evidence that methamphetamine (MA) is a widely abused drug popular among pregnant women. MA exposure is associated with changes in the function of neurotransmitter systems, namely the dopaminergic, serotonergic and glutamatergic systems. Since N -methyl- d -aspartate receptors (NMDA) are affected by MA-induced glutamate release, we assessed the expression of NMDAR subunits (NR1, NR2A, and NR2B) and postsynaptic density protein 95 (PSD-95), which is connected with NMDAR. We measured the expression of these proteins in adolescent (30 days old) and adult (60 days old) rat males exposed to MA during the entire prenatal period and compared them with the same parameters in age matched saline-exposed rats. There was a significant increase in the NR1 and NR2B subunits in the hippocampus of adult males, but not in adolescent males. We identified a significant change in adult MA-induced rats when compared to adult controls for NR2A and NR2B, while in adolescent MA rats this change was close to the boundary of significance. In summary, our study suggests that prenatal MA exposure is connected with changes in NMDAR subunit expression in adult rats but not in adolescent rats.
ISSN:0364-3190
1573-6903
DOI:10.1007/s11064-014-1381-4