P5 HER2/neu-derived peptide conjugated to liposomes containing MPL adjuvant as an effective prophylactic vaccine formulation for breast cancer

Highlights • Lip-DOPE-P5-MPL (DMPC/DMPG/Chol/DOPE/P5/MPL) is an effective peptide-based HER2/neu vaccine formulation. • Lip-DOPE-P5-MPL induces high IFN-γ production by CD8+ T cells intracellularly. • Lip-DOPE-P5-MPL induces CTL response leading to tumor growth inhibition. • Lip-DOPE-P5-MPL caused t...

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Bibliographic Details
Published in:Cancer letters 2014-12, Vol.355 (1), p.54-60
Main Authors: Shariat, Sheida, Badiee, Ali, Jalali, Seyed Amir, Mansourian, Mercedeh, Yazdani, Mona, Mortazavi, Seyed Alireza, Jaafari, Mahmoud Reza
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - administration & dosage
Animals
Antigens
Breast cancer
Breast Neoplasms - immunology
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Breast Neoplasms - prevention & control
Cancer therapies
Cancer Vaccines - administration & dosage
Cancer Vaccines - chemistry
Cancer Vaccines - immunology
Cell Line, Tumor
Chemistry, Pharmaceutical
Colleges & universities
CTL epitope
Female
Hematology, Oncology and Palliative Medicine
HER2/neu peptide
Immunization Schedule
Immunotherapy
Injections, Subcutaneous
Interferon-gamma - metabolism
Lipid A - administration & dosage
Lipid A - analogs & derivatives
Lipid A - immunology
Lipids
Lipids - chemistry
Liposomes
Lymphocytes
Mice, Inbred BALB C
MPL-Liposome
Peptide Fragments - administration & dosage
Peptide Fragments - chemistry
Peptide Fragments - immunology
Peptide vaccine
Peptides
Proteins
Radiation therapy
Receptor, ErbB-2 - administration & dosage
Receptor, ErbB-2 - chemistry
Receptor, ErbB-2 - immunology
T-Lymphocytes, Cytotoxic - drug effects
T-Lymphocytes, Cytotoxic - immunology
T-Lymphocytes, Cytotoxic - metabolism
Time Factors
Tumor Burden - drug effects
Tumors
Vaccines
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Description
Summary:Highlights • Lip-DOPE-P5-MPL (DMPC/DMPG/Chol/DOPE/P5/MPL) is an effective peptide-based HER2/neu vaccine formulation. • Lip-DOPE-P5-MPL induces high IFN-γ production by CD8+ T cells intracellularly. • Lip-DOPE-P5-MPL induces CTL response leading to tumor growth inhibition. • Lip-DOPE-P5-MPL caused the lowest tumor size and the longest survival time in mice model of TUBO tumor.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2014.09.016