Radon Inhalation Protects Against Transient Global Cerebral Ischemic Injury in Gerbils

Although brain disorders are not the main indication for radon therapy, our previous study suggested that radon inhalation therapy might mitigate brain disorders. In this study, we assessed whether radon inhalation protects against transient global cerebral ischemic injury in gerbils. Gerbils were t...

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Bibliographic Details
Published in:Inflammation 2014-10, Vol.37 (5), p.1675-1682
Main Authors: Kataoka, Takahiro, Etani, Reo, Takata, Yuji, Nishiyama, Yuichi, Kawabe, Atsushi, Kumashiro, Masayuki, Taguchi, Takehito, Yamaoka, Kiyonori
Format: Article
Language:English
Subjects:
Administration, Inhalation
Animals
Biomedical and Life Sciences
Biomedicine
Brain Ischemia - pathology
Brain Ischemia - prevention & control
Female
Gerbillinae
Immunology
Internal Medicine
Neurons - drug effects
Neurons - pathology
Neuroprotective Agents - administration & dosage
Pathology
Pharmacology/Toxicology
Radon - administration & dosage
Rheumatology
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Summary:Although brain disorders are not the main indication for radon therapy, our previous study suggested that radon inhalation therapy might mitigate brain disorders. In this study, we assessed whether radon inhalation protects against transient global cerebral ischemic injury in gerbils. Gerbils were treated with inhaled radon at a concentration of 2,000 Bq/m 3 for 24 h. After radon inhalation, transient global cerebral ischemia was induced by bilateral occlusion of the common carotid artery. Results showed that transient global cerebral ischemia induced neuronal damage in hippocampal CA1, and the number of damaged neurons was significantly increased compared with control. However, radon treatment inhibited ischemic damage. Superoxide dismutase (SOD) activity in the radon-treated gerbil brain was significantly higher than that in sham-operated gerbils. These findings suggested that radon inhalation activates antioxidative function, especially SOD, thereby inhibiting transient global cerebral ischemic injury in gerbils.
ISSN:0360-3997
1573-2576
DOI:10.1007/s10753-014-9896-z