Demonstration of the high-affinity IgE receptor (Fc sub( epsilon )RI) on Langerhans' cells of diseased nasal mucosa

Langerhans' cells in the skin have recently been shown to bind IgE molecules via the high-affinity IgE receptor (Fc sub( epsilon )RI). Using two highly specific antibodies against the antibody-binding alpha -chain of this receptor, 29C6 and 6F7, we demonstrate by immunohistochemistry and immuno...

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Bibliographic Details
Published in:Allergy (Copenhagen) 1997-04, Vol.52 (4), p.436-439
Main Authors: Haas, N, Hamann, K, Grabbe, J, Niehus, J, Kunkel, G, Kolde, G, Czarnetzki, B M
Format: Article
Language:English
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Summary:Langerhans' cells in the skin have recently been shown to bind IgE molecules via the high-affinity IgE receptor (Fc sub( epsilon )RI). Using two highly specific antibodies against the antibody-binding alpha -chain of this receptor, 29C6 and 6F7, we demonstrate by immunohistochemistry and immunoelectron microscopy that Langerhans' cells of diseased nasal mucosa can express the Fc sub( epsilon )RI. Tissue sections from hyperplastic nasal conchae and nasal polyps of atopic and nonatopic patients have shown no basic differences in epithelial Fc sub( epsilon )RI-bearing cells. Only a few cells expressed the low-affinity IgE receptor (Fc sub( epsilon )RII) (Tue1 antibody) in some sections. These findings suggest that Langerhans' cells play an important role in the induction of transepithelial IgE-mediated allergy and in the mediation of inflammation of the nasal mucosa via their Fc sub( epsilon )RI.
ISSN:0105-4538
DOI:10.1111/j.1398-9995.1997.tb01025.x