Electrochemical reduction of metronidazole at a DNA-modified glassy carbon electrode

The electrochemical reduction of metronidazole was investigated using, for the first time, the newly developed DNA-modified glassy carbon electrode. The results are compared with reduction at bare glassy carbon electrodes. The potentials for reduction were less negative when using the DNA-modified g...

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Bibliographic Details
Published in:Bioelectrochemistry and Bioenergetics 1997-05, Vol.42 (2), p.175-178
Main Authors: Brett, Ana Maria Oliveira, Serrano, S.H.P., Gutz, I., La-Scalea, M.A.
Format: Article
Language:English
Subjects:
Cyclic voltammetry
Differential pulse voltammetry
DNA-modified electrode
Glassy carbon
Nitroimidazole
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Summary:The electrochemical reduction of metronidazole was investigated using, for the first time, the newly developed DNA-modified glassy carbon electrode. The results are compared with reduction at bare glassy carbon electrodes. The potentials for reduction were less negative when using the DNA-modified glassy carbon electode although the mechanism was the same. A potential-pH dependence of one electron per proton was observed in acid media whereas for neutral and alkaline solution no dependence was found. The DNA-modified glassy carbon electrode enables preconcentration of the sample for chosen times on the electrode surface which is convenient for analytical applications. The limit of detection using the DNA-modified glassy carbon electrode at pH 4.5 with 2 min preconcentration is 1.67 μM, and without preconcentration it is three times higher, 3.25 μM. At a bare glassy carbon electrode, where preconcentration is not possible, the limit of detection for the same pH is 3.44 μM.
ISSN:0302-4598
DOI:10.1016/S0302-4598(96)05122-7