Role of protease-activated receptors for the innate immune response of the heart

Abstract Protease-activated receptors (PARs) are a family of G-protein-coupled receptors with a unique activation mechanism via cleavage by the serine proteases of the coagulation cascade, immune cell-released proteases, and proteases from pathogens. Pathogens, such as viruses and bacteria, cause my...

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Bibliographic Details
Published in:Trends in cardiovascular medicine 2014-08, Vol.24 (6), p.249-255
Main Authors: Weithauser, Alice, PhD, Rauch, Ursula, MD
Format: Article
Language:English
Subjects:
Cardiovascular
Heart
Humans
Immune system
Immunity, Innate
Infections
Interferon-beta - metabolism
Ligands
Myocarditis - immunology
Myocarditis - virology
Myocardium - immunology
Proteins
Receptors, Proteinase-Activated - metabolism
Viral infections
Virus Diseases - complications
Virus Diseases - immunology
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Summary:Abstract Protease-activated receptors (PARs) are a family of G-protein-coupled receptors with a unique activation mechanism via cleavage by the serine proteases of the coagulation cascade, immune cell-released proteases, and proteases from pathogens. Pathogens, such as viruses and bacteria, cause myocarditis and heart failure and PAR1 was shown to positively regulate the anti-viral innate immune response via interferon β during virus-induced myocarditis. In contrast, PAR2 negatively regulated the innate immune response and inhibited the interferon β expression. Thus, PARs play a central role for the innate immune response in the heart.
ISSN:1050-1738
1873-2615
DOI:10.1016/j.tcm.2014.06.004