Mutation analysis of the IL36RN gene in Chinese patients with generalized pustular psoriasis with/without psoriasis vulgaris

Highlights • Six IL36RN variants were found in 29 GPP patients, 12 PV cases and 6 controls. • The variants’ frequencies were different between GPP and PV groups. • There were also significant differences between GPP alone and GPP with PV groups. • Demonstrated that GPP and PV are distinct subtypes o...

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Bibliographic Details
Published in:Journal of dermatological science 2014-11, Vol.76 (2), p.132-138
Main Authors: Li, Xiuyan, Chen, Mingfei, Fu, Xi’an, Zhang, Qilin, Wang, Zhenzhen, Yu, Gongqi, Yu, Yongxiang, Qin, Peipei, Wu, Weizhi, Pan, Futang, Liu, Hong, Zhang, Furen
Format: Article
Language:English
Subjects:
Adolescent
Adult
Animals
Asians - genetics
Cats
Child
Child, Preschool
Dermatology
DNA Mutational Analysis
Female
Generalized pustular psoriasis (GPP)
GPP with preceding, later or accompanied by PV (GPP with PV)
GPP without psoriasis PV (GPP alone)
Humans
Interleukin 36 receptor antagonist (IL36RN)
Interleukins - genetics
Male
Middle Aged
Mutation
Mutation analysis
Psoriasis - genetics
Psoriasis vulgaris (PV)
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Summary:Highlights • Six IL36RN variants were found in 29 GPP patients, 12 PV cases and 6 controls. • The variants’ frequencies were different between GPP and PV groups. • There were also significant differences between GPP alone and GPP with PV groups. • Demonstrated that GPP and PV are distinct subtypes of psoriasis on the etiology. • GPP alone may be regarded as an especial entities of GPP different from GPP with PV.
ISSN:0923-1811
1873-569X
DOI:10.1016/j.jdermsci.2014.08.007