Estimation of serum superoxide dismutase and serum malondialdehyde in oral submucous fibrosis: a clinical and biochemical study

To estimate the level of lipid peroxidation product (MDA) and the activities of antioxidative enzymes superoxide dismutase (SOD) and the correlation of these parameters in Oral Submucous fibrosis (OSF). Estimation of MDA and SOD levels in OSF patients and controls. Patients above 15 years of age, wh...

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Bibliographic Details
Published in:Journal of cancer research and therapeutics 2014-07, Vol.10 (3), p.722-725
Main Authors: Avinash Tejasvi, M L, Bangi, Balaji Babu, Geetha, P, Anulekha Avinash, C K, Chittaranjan, B, Bhayya, Harsha, Donempudi, Pavani
Format: Article
Language:English
Subjects:
Adult
Aldehydes
Case-Control Studies
Fibrosis
Humans
Lipid Peroxidation
Malondialdehyde - blood
Measurement
Middle Aged
Mouth diseases
Oral Submucous Fibrosis - blood
Oral Submucous Fibrosis - pathology
Oxidative Stress
Physiological aspects
Superoxide dismutase
Superoxide Dismutase - blood
Young Adult
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Summary:To estimate the level of lipid peroxidation product (MDA) and the activities of antioxidative enzymes superoxide dismutase (SOD) and the correlation of these parameters in Oral Submucous fibrosis (OSF). Estimation of MDA and SOD levels in OSF patients and controls. Patients above 15 years of age, who were diagnosed as OSF based upon thorough history, clinical examination and histopathological examination without any underlying systemic diseases, were included in the present study. Equal number of healthy subjects without any deleterious habits and without any clinically obvious oral lesions or systemic diseases were selected as the control group. The estimation of MDA in serum was done by thiobarbituric acid reactive species method. SOD was assayed by inhibition and autoxidation of adrenaline method. The data were analyzed with Student's t-test. Comparison of MDA, SOD among the OSF group and control group showed statistically significant increased levels of malondialdehyde and decreased levels of superoxide dismutase among the OSF groups. Significant changes were not seen in MDA and SOD levels between the different grades of OSF. From the present study, estimation of lipid peroxidation like MDA was done, which showed increased levels in the OSF group compared to the control group and antioxidant enzyme levels like SOD showed decreased levels in the OSF group compared to the control group. These can be considered as a subject of interest for their possible role in many of the precancerous and cancerous conditions.
ISSN:0973-1482
1998-4138
DOI:10.4103/0973-1482.139160