Circulating miR-1, miR-133a, and miR-206 levels are increased after a half-marathon run

Abstract Context: Circulating miRNAs are potential biomarkers that can be important molecules driving cell-to-cell communication. Objective: To investigate circulating muscle-specific miRNAs in recreational athletes. Materials and methods: Three miRNAs from whole plasma before and after a half-marat...

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Bibliographic Details
Published in:Biomarkers 2014-11, Vol.19 (7), p.585-589
Main Authors: Gomes, Clarissa P. C., Oliveira-Jr, Getúlio P., Madrid, Bibiano, Almeida, Jeeser A., Franco, Octávio L., Pereira, Rinaldo W.
Format: Article
Language:English
Subjects:
Adult
Exercise
extracellular vesicles
Genetic Markers
Humans
Male
microRNA
MicroRNAs - blood
Physical Endurance - genetics
plasma
quantitative PCR
Real-Time Polymerase Chain Reaction
Running
Time Factors
Up-Regulation
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Summary:Abstract Context: Circulating miRNAs are potential biomarkers that can be important molecules driving cell-to-cell communication. Objective: To investigate circulating muscle-specific miRNAs in recreational athletes. Materials and methods: Three miRNAs from whole plasma before and after a half-marathon were analyzed by qPCR. Results: MiR-1, −133a, and −206 significantly increased after the race. Discussion: Increased levels of miRNAs after exercise point to potential biomarkers and to the possibility of being functional players following endurance training. Conclusion: These miRNAs are potential biomarkers of muscle damage or adaptation to exercise.
ISSN:1354-750X
1366-5804
DOI:10.3109/1354750X.2014.952663