Acute antidepressant treatment differently modulates ERK/MAPK activation in neurons and astrocytes of the adult mouse prefrontal cortex

• Published in: Neuroscience 2013-03, Vol.232, p.161-168
• Main Authors: Di Benedetto, B, Radecke, J, Schmidt, M.V, Rupprecht, R
• Format: Article
• Language: English
• Subjects: Animals; antidepressants; Antidepressive Agents - pharmacology; astrocyte; Astrocytes - drug effects; Astrocytes - enzymology; Biological and medical sciences; Blotting, Western; Corpus Striatum - drug effects; Corpus Striatum - enzymology; Desipramine - pharmacology; ERK; Fluorescent Antibody Technique; Fluoxetine - pharmacology; Hippocampus - drug effects; Hippocampus - enzymology; Male; Medical sciences; Mice; Microscopy, Confocal; Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors; Mitogen-Activated Protein Kinase 1 - metabolism; Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors; Mitogen-Activated Protein Kinase 3 - metabolism; mouse; Neurology; neuron; Neurons - drug effects; Neurons - enzymology; Neuropharmacology; Pharmacology. Drug treatments; prefrontal cortex; Prefrontal Cortex - drug effects; Prefrontal Cortex - enzymology; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopharmacology
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2012.11.061

Graphical abstract Highlights ► We examine acute effects of antidepressants (ADs) on ERK activity in the adult mouse. ► At basal conditions ERK activity is mostly displayed in neurons, less in astrocytes. ► ADs inhibit neuronal ERK in the prefrontal cortex 15 min after administration. ► ADs do not evidently affect astrocytic ERK at this time point. ► Fluoxetine acts in superficial and deep cortical layers, desipramine in deep ones.