Sesamin suppresses activation of microglia and p44/42 MAPK pathway, which confers neuroprotection in rat intracerebral hemorrhage

• Published in: Neuroscience 2013-03, Vol.232, p.45-52
• Main Authors: Ohnishi, M, Monda, A, Takemoto, R, Matsuoka, Y, Kitamura, C, Ohashi, K, Shibuya, H, Inoue, A
• Format: Article
• Language: English
• Subjects: Animals; Antioxidants - pharmacology; Biological and medical sciences; Brain - drug effects; Brain - enzymology; Brain - pathology; Cell Death - drug effects; Cell Proliferation - drug effects; Cells, Cultured; Cerebral Hemorrhage - drug therapy; Cerebral Hemorrhage - enzymology; Cerebral Hemorrhage - pathology; Dioxoles - pharmacology; Disease Models, Animal; intracerebral hemorrhage; Lignans - pharmacology; Male; MAP Kinase Signaling System - drug effects; Medical sciences; microglia; Microglia - drug effects; Microglia - enzymology; Mitogen-Activated Protein Kinase 1 - metabolism; Mitogen-Activated Protein Kinase 3 - metabolism; Neurology; Neurons - drug effects; Neurons - pathology; Neuropharmacology; neuroprotection; Neuroprotective agent; Neuroprotective Agents - pharmacology; Nitric Oxide - metabolism; Nitric Oxide Synthase Type II - metabolism; p38 Mitogen-Activated Protein Kinases - metabolism; p44/42 MAPK; Pharmacology. Drug treatments; Rats, Sprague-Dawley; Rats, Wistar; sesamin; thrombin; Vascular diseases and vascular malformations of the nervous system
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2012.11.057

Highlights ► Thrombin activates MAPK and primary-cultured rat microglia. ► Sesamin suppresses the activation of p44/42 MAPK and cultured microglia. ► Hemorrhagic neuron injury is involved in activated p44/42 MAPK and microglia. ► Sesamin suppresses the activation of p44/42 MAPK and microglia in vivo . ► Sesamin confers neuroprotection.