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Sesamin suppresses activation of microglia and p44/42 MAPK pathway, which confers neuroprotection in rat intracerebral hemorrhage
Highlights ► Thrombin activates MAPK and primary-cultured rat microglia. ► Sesamin suppresses the activation of p44/42 MAPK and cultured microglia. ► Hemorrhagic neuron injury is involved in activated p44/42 MAPK and microglia. ► Sesamin suppresses the activation of p44/42 MAPK and microglia in vivo...
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| Published in: | Neuroscience 2013-03, Vol.232, p.45-52 |
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| Main Authors: | , , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c531t-521465e8d0f21982e3b62f62c3617c691a00c83733924112b12d050ccb27f2133 |
| container_end_page | 52 |
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| container_start_page | 45 |
| container_title | Neuroscience |
| container_volume | 232 |
| creator | Ohnishi, M Monda, A Takemoto, R Matsuoka, Y Kitamura, C Ohashi, K Shibuya, H Inoue, A |
| description | Highlights ► Thrombin activates MAPK and primary-cultured rat microglia. ► Sesamin suppresses the activation of p44/42 MAPK and cultured microglia. ► Hemorrhagic neuron injury is involved in activated p44/42 MAPK and microglia. ► Sesamin suppresses the activation of p44/42 MAPK and microglia in vivo . ► Sesamin confers neuroprotection. |
| doi_str_mv | 10.1016/j.neuroscience.2012.11.057 |
| format | article |
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Drug treatments ; Rats, Sprague-Dawley ; Rats, Wistar ; sesamin ; thrombin ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Neuroscience, 2013-03, Vol.232, p.45-52</ispartof><rights>IBRO</rights><rights>2012 IBRO</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2012 IBRO. Published by Elsevier Ltd. 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Drug treatments</subject><subject>Rats, Sprague-Dawley</subject><subject>Rats, Wistar</subject><subject>sesamin</subject><subject>thrombin</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqNUk1v1DAUtBCILgt_AVlISBxI6mcncZYDUlU-RRFIhbPlOC-Nl8QOdtJqj_xzvN3lQ5zw5V1m5o1nHiFPgOXAoDrd5g6X4KOx6AzmnAHPAXJWyjtkBbUUmSyL4i5ZMcGqrCg5PyEPYtyy9MpC3CcnXHBe18BW5MclRj1aR-MyTQFjxEi1me21nq131Hd0tCb4q8Fqql1Lp6I4LTj9ePb5A5303N_o3XN601vTU-NdhyHSW3NT8DOaW40kHvScxhy0wYBN0APtcfQh9PoKH5J7nR4iPjrONfn65vWX83fZxae378_PLjJTCpizkkNRlVi3rOOwqTmKpuJdxY2oQJpqA5oxUwspxIYXALwB3rKSGdNwmRhCrMmzg26y9n3BOKvRRoPDoB36JSqoQGxKVgueoC8O0PTzGAN2agp21GGngKl9BWqr_q5A7StQACpVkMiPj3uWZsT2N_VX5gnw9AjQ0eihC9oZG__gJDAmk-M1eXXAYUrl2mJQx3WtDSla1Xr7f35e_iNjButs2vwNdxi3fgku5a5ARa6Yutwfzf5mIImAFJX4CfqhwF4</recordid><startdate>20130301</startdate><enddate>20130301</enddate><creator>Ohnishi, M</creator><creator>Monda, A</creator><creator>Takemoto, R</creator><creator>Matsuoka, Y</creator><creator>Kitamura, C</creator><creator>Ohashi, K</creator><creator>Shibuya, H</creator><creator>Inoue, A</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130301</creationdate><title>Sesamin suppresses activation of microglia and p44/42 MAPK pathway, which confers neuroprotection in rat intracerebral hemorrhage</title><author>Ohnishi, M ; Monda, A ; Takemoto, R ; Matsuoka, Y ; Kitamura, C ; Ohashi, K ; Shibuya, H ; Inoue, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c531t-521465e8d0f21982e3b62f62c3617c691a00c83733924112b12d050ccb27f2133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Antioxidants - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Brain - drug effects</topic><topic>Brain - enzymology</topic><topic>Brain - pathology</topic><topic>Cell Death - drug effects</topic><topic>Cell Proliferation - drug effects</topic><topic>Cells, Cultured</topic><topic>Cerebral Hemorrhage - drug therapy</topic><topic>Cerebral Hemorrhage - enzymology</topic><topic>Cerebral Hemorrhage - pathology</topic><topic>Dioxoles - pharmacology</topic><topic>Disease Models, Animal</topic><topic>intracerebral hemorrhage</topic><topic>Lignans - pharmacology</topic><topic>Male</topic><topic>MAP Kinase Signaling System - drug effects</topic><topic>Medical sciences</topic><topic>microglia</topic><topic>Microglia - drug effects</topic><topic>Microglia - enzymology</topic><topic>Mitogen-Activated Protein Kinase 1 - metabolism</topic><topic>Mitogen-Activated Protein Kinase 3 - metabolism</topic><topic>Neurology</topic><topic>Neurons - drug effects</topic><topic>Neurons - pathology</topic><topic>Neuropharmacology</topic><topic>neuroprotection</topic><topic>Neuroprotective agent</topic><topic>Neuroprotective Agents - pharmacology</topic><topic>Nitric Oxide - metabolism</topic><topic>Nitric Oxide Synthase Type II - metabolism</topic><topic>p38 Mitogen-Activated Protein Kinases - metabolism</topic><topic>p44/42 MAPK</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats, Sprague-Dawley</topic><topic>Rats, Wistar</topic><topic>sesamin</topic><topic>thrombin</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ohnishi, M</creatorcontrib><creatorcontrib>Monda, A</creatorcontrib><creatorcontrib>Takemoto, R</creatorcontrib><creatorcontrib>Matsuoka, Y</creatorcontrib><creatorcontrib>Kitamura, C</creatorcontrib><creatorcontrib>Ohashi, K</creatorcontrib><creatorcontrib>Shibuya, H</creatorcontrib><creatorcontrib>Inoue, A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ohnishi, M</au><au>Monda, A</au><au>Takemoto, R</au><au>Matsuoka, Y</au><au>Kitamura, C</au><au>Ohashi, K</au><au>Shibuya, H</au><au>Inoue, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sesamin suppresses activation of microglia and p44/42 MAPK pathway, which confers neuroprotection in rat intracerebral hemorrhage</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2013-03-01</date><risdate>2013</risdate><volume>232</volume><spage>45</spage><epage>52</epage><pages>45-52</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><coden>NRSCDN</coden><abstract>Highlights ► Thrombin activates MAPK and primary-cultured rat microglia. ► Sesamin suppresses the activation of p44/42 MAPK and cultured microglia. ► Hemorrhagic neuron injury is involved in activated p44/42 MAPK and microglia. ► Sesamin suppresses the activation of p44/42 MAPK and microglia in vivo . ► Sesamin confers neuroprotection.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>23228810</pmid><doi>10.1016/j.neuroscience.2012.11.057</doi><tpages>8</tpages></addata></record> |
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| ispartof | Neuroscience, 2013-03, Vol.232, p.45-52 |
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| subjects | Animals Antioxidants - pharmacology Biological and medical sciences Brain - drug effects Brain - enzymology Brain - pathology Cell Death - drug effects Cell Proliferation - drug effects Cells, Cultured Cerebral Hemorrhage - drug therapy Cerebral Hemorrhage - enzymology Cerebral Hemorrhage - pathology Dioxoles - pharmacology Disease Models, Animal intracerebral hemorrhage Lignans - pharmacology Male MAP Kinase Signaling System - drug effects Medical sciences microglia Microglia - drug effects Microglia - enzymology Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Neurology Neurons - drug effects Neurons - pathology Neuropharmacology neuroprotection Neuroprotective agent Neuroprotective Agents - pharmacology Nitric Oxide - metabolism Nitric Oxide Synthase Type II - metabolism p38 Mitogen-Activated Protein Kinases - metabolism p44/42 MAPK Pharmacology. Drug treatments Rats, Sprague-Dawley Rats, Wistar sesamin thrombin Vascular diseases and vascular malformations of the nervous system |
| title | Sesamin suppresses activation of microglia and p44/42 MAPK pathway, which confers neuroprotection in rat intracerebral hemorrhage |
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