Allergy to Amoxicillin in Patients Who Tolerated Benzylpenicillin, Aztreonam, and Ceftazidime

The usual battery of skin tests employed for determining penicillin allergy may fail to detect allergic reactions to side chain-specific β-lactam agents. We report the cases of six patients who experienced anaphylactic reactions after treatment and challenge with amoxicillin but who tolerated parent...

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Bibliographic Details
Published in:Clinical infectious diseases 1992-02, Vol.14 (2), p.592-593
Main Authors: Martin, Jose A., Igea, Juan M., Fraj, Juan, Lezaun, Apolinar, Parra, Fernando, Losada, Eloy
Format: Article
Language:English
Subjects:
Adolescent
Adult
Allergies
Allergy tests
Amoxicillin - adverse effects
Anaphylaxis
Aztreonam - adverse effects
Ceftazidime - adverse effects
Dosage
Drug Hypersensitivity - diagnosis
Drug Tolerance
Female
Humans
Hypotension
Intradermal Tests
Male
Middle Aged
Penicillin
Penicillin G - adverse effects
Reagents
Skin Tests
Urticaria
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Description
Summary:The usual battery of skin tests employed for determining penicillin allergy may fail to detect allergic reactions to side chain-specific β-lactam agents. We report the cases of six patients who experienced anaphylactic reactions after treatment and challenge with amoxicillin but who tolerated parenteral challenges with benzylpenicillin, aztreonam, and ceftazidime. Results of skin tests for amoxicillin (10 mg/mL) were positive for four of the six patients.
ISSN:1058-4838
1537-6591
DOI:10.1093/clinids/14.2.592