On the safety of Bacillus subtilis and B. amyloliquefaciens : a review

An overwhelming majority of recombinant microorganisms to be used by industry are expected to be based on harmless hosts. Many of these have been proven safe over many years of experience in industrial settings. Furthermore, extensive information on the incapacity to cause disease, i.e. non-pathogen...

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Bibliographic Details
Published in:Applied microbiology and biotechnology 1991-10, Vol.36 (1), p.1-4
Main Authors: SIETSKE DE BOER, A, DIDERICHSEN, B
Format: Article
Language:English
Subjects:
Adult
Animals
Bacillus - pathogenicity
Bacillus amyloliquefaciens
Bacillus subtilis - pathogenicity
Bacteriology
Biological and medical sciences
Child
DNA, Recombinant
Drug Contamination
fermentation
Foodborne Diseases - epidemiology
Foodborne Diseases - microbiology
Fundamental and applied biological sciences. Psychology
Genetic Engineering
genetics
Gram-Positive Bacterial Infections - complications
Gram-Positive Bacterial Infections - epidemiology
Gram-Positive Bacterial Infections - microbiology
Heroin
host systems
Humans
Immunocompromised Host
Industrial Microbiology
Infant
Mice
Microbiology
Neoplasms - complications
Opportunistic Infections - complications
Opportunistic Infections - epidemiology
Opportunistic Infections - microbiology
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Retrospective Studies
Safety
Substance Abuse, Intravenous - complications
Virulence
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Summary:An overwhelming majority of recombinant microorganisms to be used by industry are expected to be based on harmless hosts. Many of these have been proven safe over many years of experience in industrial settings. Furthermore, extensive information on the incapacity to cause disease, i.e. non-pathogenic and non-toxicogenic potential, of some of these organisms can be found in the literature. We believe that a review of the literature and present experience with some of these host organisms will be useful for assessment of the safety of many recombinant organisms.
ISSN:0175-7598
1432-0614
DOI:10.1007/bf00164689