Fosinopril improves the electrophysiological characteristics of left ventricular hypertrophic myocardium in spontaneously hypertensive rats

• Published in: Naunyn-Schmiedeberg's archives of pharmacology 2014-11, Vol.387 (11), p.1037-1044
• Main Authors: Huang, Zhi-Bin, Deng, Chun-Yu, Lin, Mao-Huan, Yuan, Gui-Yi, Wu, Wei
• Format: Article
• Language: English
• Subjects: Animals; Antihypertensive Agents - pharmacology; Biomedical and Life Sciences; Biomedicine; Calcium; Calcium channels (L-type); Calcium Channels, L-Type - metabolism; Cardiac muscle; Electrophysiological Phenomena - drug effects; Eutrophication; Fibrillation; Fosinopril - pharmacology; Heart; Hypertension; Hypertrophy, Left Ventricular - drug therapy; Hypertrophy, Left Ventricular - physiopathology; Male; Myocardium; Myocytes; Myocytes, Cardiac - drug effects; Myocytes, Cardiac - metabolism; Neurosciences; Original Article; Patch-Clamp Techniques; Pharmacology/Toxicology; Potassium; Potassium Channels - metabolism; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rodents; Sodium; Sodium Channels - metabolism; Ventricle
• ISSN: 0028-1298; 1432-1912
• DOI: 10.1007/s00210-014-1024-y

This study investigated the effects of fosinopril on the electrophysiological characteristics of the left ventricular hypertrophic myocardium in spontaneously hypertensive rats (SHRs). Twenty-four 10-week-old male SHRs were divided into fosinopril and non-fosinopril groups ( n  = 12 each). Twelve 10-week-old Wistar–Kyoto rats were used a control group. Left ventricular mass index and ventricular fibrillation threshold (VFT) were measured after 8 weeks of fosinopril or saline treatment. L-type calcium current ( I CaL ), sodium current ( I Na ), and transient outward potassium current ( I to ) were measured in left ventricular myocytes after 8 weeks of fosinopril or saline treatment using the whole-cell patch-clamp technique. VFT was higher in the fosinopril group than in the non-fosinopril group (17.5 ± 1.2 mA vs. 15.6 ± 1.1 mA, P