Canonical transient receptor potential channel 2 (TRPC2): old name–new games. Importance in regulating of rat thyroid cell physiology

In addition to the TSH-cyclic AMP signalling pathway, calcium signalling is of crucial importance in thyroid cells. Although the importance of calcium signalling has been thoroughly investigated for several decades, the nature of the calcium channels involved in signalling is unknown. In a recent se...

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Bibliographic Details
Published in:Pflügers Archiv 2014-11, Vol.466 (11), p.2025-2034
Main Authors: Törnquist, Kid, Sukumaran, Pramod, Kemppainen, Kati, Löf, Christoffer, Viitanen, Tero
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Calcium - metabolism
Cell Biology
Cell Physiological Phenomena - physiology
Human Physiology
Humans
Invited Review
Molecular Medicine
Neurosciences
Rats
Receptors
Receptors, Thyrotropin - metabolism
Thyroglobulin - metabolism
Thyroid Gland - metabolism
Thyroid Gland - physiology
TRPC Cation Channels - metabolism
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Summary:In addition to the TSH-cyclic AMP signalling pathway, calcium signalling is of crucial importance in thyroid cells. Although the importance of calcium signalling has been thoroughly investigated for several decades, the nature of the calcium channels involved in signalling is unknown. In a recent series of investigations using the well-studied rat thyroid FRTL-5 cell line, we showed that these cells exclusively express the transient receptor potential canonical 2 (TRPC2) channel. Our results suggested that the TRPC2 channel is of significant importance in regulating thyroid cell function. These investigations were the first to show that thyroid cells express a member of the TRPC family of ion channels. In this review, we will describe the importance of the TRPC2 channel in regulating TSH receptor expression, thyroglobulin maturation, intracellular calcium and iodide homeostasis and that the channel also regulates thyroid cell proliferation.
ISSN:0031-6768
1432-2013
DOI:10.1007/s00424-014-1509-z