Short- and long-term results of modified Frey's procedure in patients with chronic pancreatitis: a retrospective Japanese single-center study

The study aim was to determine the short- and long-term results of surgical drainage procedure for chronic pancreatitis at a single center in Japan. The records of 28 consecutive patients were retrospectively reviewed. All patients underwent surgery at Kobe University Hospital between June 1999 and...

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Bibliographic Details
Published in:Kobe journal of the medical sciences 2014, Vol.60 (2), p.E30-E36
Main Authors: Tanaka, Masaki, Matsumoto, Ippei, Shinzeki, Makoto, Asari, Sadaki, Goto, Tadahiro, Yamashita, Hironori, Ishida, Jun, Ajiki, Tetsuo, Fukumoto, Takumi, Ku, Yonson
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Drainage - methods
Female
Humans
Japan
Male
Middle Aged
Pain
Pain Management
Pancreatectomy
Pancreaticojejunostomy
Pancreatitis, Alcoholic - physiopathology
Pancreatitis, Alcoholic - surgery
Pancreatitis, Chronic - etiology
Pancreatitis, Chronic - physiopathology
Pancreatitis, Chronic - surgery
Postoperative Complications - epidemiology
Retrospective Studies
Treatment Outcome
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Summary:The study aim was to determine the short- and long-term results of surgical drainage procedure for chronic pancreatitis at a single center in Japan. The records of 28 consecutive patients were retrospectively reviewed. All patients underwent surgery at Kobe University Hospital between June 1999 and April 2013. Long-term follow-up was performed in all patients for a median period of 77 months. The 26 men (93%) and 2 women (7%) had a mean age of 47 years. The etiology of pancreatitis was chronic alcohol abuse in 24 patients (86%). The major indication for surgery was persistent symptoms (97%). Modified Frey's procedure in 21 patients, lateral pancreaticojejunostomy (LPJ) in 6 patients, LPJ and distal pancreatectomy in one patient, were performed. There was no postoperative mortality. Postoperative morbidity occurred in 6 patients (21%). The percentage of pain-free patients after surgery was 97%, and further acute exacerbation was prevented in 97%. Two patients (6%) required subsequent surgery for infectious pancreatic cyst and intraabdominal abscess. Of the patients that completed follow-up, 13 (46%) had diabetes mellitus, including 5 patients (19%) with new-onset diabetes, and 6 patients (19%) developed pancreatic exocrine insufficiency. Modified Frey's procedure is safe, feasible, and effective to manage chronic pancreatitis. The technique prevents further exacerbations and maintains appropriate pancreatic endocrine and exocrine function.
ISSN:1883-0498