The panoply of αβT cells in the skin

Highlights • Most skin αβT cells are skin-tropic resident memory cells. • CD8 T cells reside in epidermis. • CD4 T cells and regulatory T cells reside in dermis. • Features of skin αβT cell-subsets are reviewed. • Harnessing immune system is becoming a promising approach to treat melanoma....

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Bibliographic Details
Published in:Journal of dermatological science 2014-10, Vol.76 (1), p.3-9
Main Authors: Nomura, Takashi, Kabashima, Kenji, Miyachi, Yoshiki
Format: Article
Language:English
Subjects:
Animals
CD4T cells
CD8-Positive T-Lymphocytes - immunology
CD8T cells
Cell Differentiation
Cell Membrane - metabolism
Cytokines - metabolism
Dermatitis, Atopic - immunology
Dermatology
Drug Eruptions - immunology
Forkhead Transcription Factors - metabolism
Humans
Hypersensitivity
Innate-like T cells
Interleukin-10 - metabolism
Interleukin-17 - immunology
Keratinocytes - cytology
Killer Cells, Natural - immunology
Lichen Planus - immunology
Memory T cells
Mice
Phenotype
Regulatory T cells
Skin - immunology
Skin - pathology
Skin T cells
T-Lymphocytes - cytology
T-Lymphocytes, Helper-Inducer - immunology
Th1 Cells - immunology
Th2 Cells - immunology
Transforming Growth Factor beta - metabolism
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Summary:Highlights • Most skin αβT cells are skin-tropic resident memory cells. • CD8 T cells reside in epidermis. • CD4 T cells and regulatory T cells reside in dermis. • Features of skin αβT cell-subsets are reviewed. • Harnessing immune system is becoming a promising approach to treat melanoma.
ISSN:0923-1811
1873-569X
DOI:10.1016/j.jdermsci.2014.07.010