Age effects on the default mode and control networks in typically developing children

• Published in: Journal of psychiatric research 2014-11, Vol.58, p.89-95
• Main Authors: Sato, João Ricardo, Salum, Giovanni Abrahão, Gadelha, Ary, Picon, Felipe Almeida, Pan, Pedro Mario, Vieira, Gilson, Zugman, André, Hoexter, Marcelo Queiroz, Anés, Mauricio, Moura, Luciana Monteiro, Gomes Del'Aquilla, Marco Antonio, Amaro, Edson, McGuire, Philip, Crossley, Nicolas, Lacerda, Acioly, Rohde, Luis Augusto, Miguel, Euripedes Constantino, Bressan, Rodrigo Affonseca, Jackowski, Andrea Parolin
• Format: Article
• Language: English
• Subjects: Adolescent; Aging; Biological and medical sciences; Brain - anatomy & histology; Brain - blood supply; Brain - growth & development; Brain Mapping; Brain networks; Child; Child Development; Cohort Studies; Female; Graph theory; Healthy; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Medical sciences; Neural Pathways - blood supply; Neural Pathways - physiology; Neurodevelopment; Neuroimaging; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Rest; Typical development
• ISSN: 0022-3956; 1879-1379
• DOI: 10.1016/j.jpsychires.2014.07.004

Abstract Background The investigation of neurodevelopment during late childhood and pre-adolescence has recently attracted a great deal of interest in the field of neuroimaging. One promising topic in this field is the formation of brain networks in healthy subjects. The integration between neural modules characterizes the ability of the network to process information globally. Although many fMRI-based neurodevelopment studies can be found in the literature, the analyses of very large samples (on the order of hundreds of subjects) that focus on the late childhood/pre-adolescence period and resting state fMRI are scarce, and most studies have focused solely on North American and European populations. Aims In this study, we present a descriptive investigation of the developmental formation of the Default Mode Network and the Control Network based on a Brazilian, cross-sectional community sample of 447 typically developing subjects aged 7–15 years old. Methods Resting state fMRI data were acquired using two MRI systems from the same manufacturer using the same acquisition parameters. We estimated the age effects on the strength of the links (between brain regions) and the network features (graph descriptors: degree and eigenvector centrality). Results Our findings showed an increase in the antero-posterior connectivity in both studied networks during brain development. The graph analyses showed an increase in centrality with age for most regions in the Default Mode Network and the dorsal anterior and posterior cingulate, the right anterior insula and the left posterior temporal cortex in the Control Network. Conclusion We conclude that the period of 7–15 years of age is crucial for the development of both the Default Mode and Control networks, with integration between the posterior and anterior neuronal modules and an increase in the centrality measures of the hub regions.