Therapeutic strategies for treating osteolytic bone metastases

•Increased incidence of bone metastases requires adapted therapeutic strategies.•Therapeutic objectives: relieve severe pain and improve the functional prognosis.•Global patient management includes local approach and pharmacological treatment.•Pharmacological approach involves inhibiting bone resorp...

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Bibliographic Details
Published in:Drug discovery today 2014-09, Vol.19 (9), p.1419-1426
Main Authors: Verron, Elise, Schmid-Antomarchi, Heidy, Pascal-Mousselard, Hugues, Schmid-Alliana, Annie, Scimeca, Jean-Claude, Bouler, Jean-Michel
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - therapeutic use
Biochemistry
Biochemistry, Molecular Biology
Bioengineering
Biomaterials
Bone Density Conservation Agents
Bone Density Conservation Agents - therapeutic use
Bone Neoplasms
Bone Neoplasms - pathology
Bone Neoplasms - secondary
Bone Neoplasms - therapy
Cancer
Cell Behavior
Cellular Biology
Genomics
Human health and pathology
Humans
Life Expectancy
Life Sciences
Molecular biology
Osteolysis
Osteolysis - pathology
Osteolysis - therapy
Prognosis
Quality of Life
Rhumatology and musculoskeletal system
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Summary:•Increased incidence of bone metastases requires adapted therapeutic strategies.•Therapeutic objectives: relieve severe pain and improve the functional prognosis.•Global patient management includes local approach and pharmacological treatment.•Pharmacological approach involves inhibiting bone resorption and tumor vascularization. The recent progress in oncologic management of patients with localized cancer or metastatic disease has permitted a significant improvement in life expectancy. Nevertheless, bone metastases and their consequent skeletal-related events (SREs) are still associated with unfavorable prognosis and greatly affect quality of life. Global management of these bone metastases includes traditional local approaches (surgery, radiotherapy, etc.) and systemic administration of chemotherapeutic agents. This review focuses on treatments specific for bone metastases and, in particular, on inhibitors of bone resorption that are effective for preventing and delaying the development of SREs.
ISSN:1359-6446
1741-8364
1878-5832
DOI:10.1016/j.drudis.2014.04.004