Genetic Markers in Adult High-Grade Gliomas

Diffuse gliomas are the most common primary central nervous system malignancy in adults and most are high grade. Although current morphologic classification by the World Health Organization provides considerable information, significant variability continues to exist in each diagnostic category. Rec...

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Bibliographic Details
Published in:Seminars in radiation oncology 2014-10, Vol.24 (4), p.235-239
Main Authors: Pekmezci, Melike, MD, Perry, Arie, MD
Format: Article
Language:English
Subjects:
Adult
Central Nervous System Neoplasms - diagnosis
Central Nervous System Neoplasms - genetics
Gene Expression Profiling - methods
Genetic Markers
Glioma - diagnosis
Glioma - genetics
Hematology, Oncology and Palliative Medicine
Humans
Radiology
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Summary:Diffuse gliomas are the most common primary central nervous system malignancy in adults and most are high grade. Although current morphologic classification by the World Health Organization provides considerable information, significant variability continues to exist in each diagnostic category. Recent molecular advances define distinct molecular signatures and elucidate gliomagenesis pathways, leading to alternative methods for subclassification beyond morphology alone. In addition, each newly described molecular aberration represents a potential new biomarker with variable diagnostic, prognostic, and predictive value for further guiding patient management. In this review, we summarize the most commonly used genetic biomarkers in the workup of adult high-grade gliomas.
ISSN:1053-4296
1532-9461
DOI:10.1016/j.semradonc.2014.06.005