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Anthelmintic resistance in ovine gastrointestinal nematodes in inland southern Queensland
OBJECTIVE: To establish the prevalence of anthelmintic resistance in ovine gastrointestinal nematodes in southern Queensland. DESIGN: An observational parasitological study using the faecal egg count reduction test. METHODS: Sheep farms (n = 20) enrolled in this study met the twin criteria of using...
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| Published in: | Australian veterinary journal 2014-11, Vol.92 (11), p.415-420 |
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| Language: | English |
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| container_end_page | 420 |
| container_issue | 11 |
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| container_title | Australian veterinary journal |
| container_volume | 92 |
| creator | Lyndal‐Murphy, M Ehrlich, WK Mayer, DG |
| description | OBJECTIVE: To establish the prevalence of anthelmintic resistance in ovine gastrointestinal nematodes in southern Queensland. DESIGN: An observational parasitological study using the faecal egg count reduction test. METHODS: Sheep farms (n = 20) enrolled in this study met the twin criteria of using worm testing for drench decisions and having concerns about anthelmintic efficacy. On each farm, 105 sheep were randomly allocated to one of six treatment groups or an untreated control group. Faecal samples were collected on day 0 and days 10–14 for worm egg counts and larval differentiation. Single‐ and multi‐combination anthelmintics, persistent and non‐persistent, oral liquid or capsule, pour‐on and injectable formulations were tested. Monepantel was not tested. Farmers also responded to a questionnaire on drenching practices. RESULTS: Haemonchus contortus was the predominant species. Efficacy |
| doi_str_mv | 10.1111/avj.12250 |
| format | article |
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DESIGN: An observational parasitological study using the faecal egg count reduction test. METHODS: Sheep farms (n = 20) enrolled in this study met the twin criteria of using worm testing for drench decisions and having concerns about anthelmintic efficacy. On each farm, 105 sheep were randomly allocated to one of six treatment groups or an untreated control group. Faecal samples were collected on day 0 and days 10–14 for worm egg counts and larval differentiation. Single‐ and multi‐combination anthelmintics, persistent and non‐persistent, oral liquid or capsule, pour‐on and injectable formulations were tested. Monepantel was not tested. Farmers also responded to a questionnaire on drenching practices. RESULTS: Haemonchus contortus was the predominant species. Efficacy <95% was recorded on 85% of farms for one or more anthelmintics and on 10% of farms for six anthelmintics. No resistance was identified on three farms. The 4‐way combination product was efficacious (n = 4 farms). Napthalophos resistance was detected on one farm only. Resistance to levamisole (42% of farms), moxidectin injection (50% of farms) and the closantel/abamectin combination (67% of farms) was identified. Moxidectin oral was efficacious against Trichostrongylus colubriformis, which was predominant on only one farm. Of the farms tested, 55% ran meat breeds, 60% dosed more than the recommended dose rate and 70% always, mostly or when possible practised a ‘drench and move’ strategy. CONCLUSION: This level of anthelmintic resistance in southern Queensland will severely compromise worm control and force increased use of monepantel.</description><identifier>ISSN: 0005-0423</identifier><identifier>EISSN: 1751-0813</identifier><identifier>DOI: 10.1111/avj.12250</identifier><identifier>PMID: 25348144</identifier><language>eng</language><publisher>England: Australian Veterinary Association</publisher><subject>abamectin ; Animal Husbandry ; Animals ; anthelmintic resistance ; Anthelmintics - pharmacology ; breeds ; closantel ; Drug Resistance, Microbial - drug effects ; eggs ; faecal egg count reduction test ; farmers ; Farms ; fecal egg count ; feces ; gastrointestinal nematodes ; Haemonchus contortus ; larvae ; levamisole ; meat ; moxidectin ; Nematoda - drug effects ; nematode control ; Nematode Infections - drug therapy ; Nematode Infections - veterinary ; Parasite Egg Count - veterinary ; Queensland ; questionnaires ; Sheep ; Sheep Diseases - drug therapy ; Surveys and Questionnaires ; Trichostrongylus colubriformis</subject><ispartof>Australian veterinary journal, 2014-11, Vol.92 (11), p.415-420</ispartof><rights>2014 The State of Queensland (through the Department of Agriculture, Fisheries and Forestry) . Australian Veterinary Journal © 2014 Australian Veterinary Association</rights><rights>2014 The State of Queensland (through the Department of Agriculture, Fisheries and Forestry) . Australian Veterinary Journal © 2014 Australian Veterinary Association.</rights><rights>Copyright © 2014 Australian Veterinary Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0001-9564-9176</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25348144$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lyndal‐Murphy, M</creatorcontrib><creatorcontrib>Ehrlich, WK</creatorcontrib><creatorcontrib>Mayer, DG</creatorcontrib><title>Anthelmintic resistance in ovine gastrointestinal nematodes in inland southern Queensland</title><title>Australian veterinary journal</title><addtitle>Aust Vet J</addtitle><description>OBJECTIVE: To establish the prevalence of anthelmintic resistance in ovine gastrointestinal nematodes in southern Queensland. DESIGN: An observational parasitological study using the faecal egg count reduction test. METHODS: Sheep farms (n = 20) enrolled in this study met the twin criteria of using worm testing for drench decisions and having concerns about anthelmintic efficacy. On each farm, 105 sheep were randomly allocated to one of six treatment groups or an untreated control group. Faecal samples were collected on day 0 and days 10–14 for worm egg counts and larval differentiation. Single‐ and multi‐combination anthelmintics, persistent and non‐persistent, oral liquid or capsule, pour‐on and injectable formulations were tested. Monepantel was not tested. Farmers also responded to a questionnaire on drenching practices. RESULTS: Haemonchus contortus was the predominant species. Efficacy <95% was recorded on 85% of farms for one or more anthelmintics and on 10% of farms for six anthelmintics. No resistance was identified on three farms. The 4‐way combination product was efficacious (n = 4 farms). Napthalophos resistance was detected on one farm only. Resistance to levamisole (42% of farms), moxidectin injection (50% of farms) and the closantel/abamectin combination (67% of farms) was identified. Moxidectin oral was efficacious against Trichostrongylus colubriformis, which was predominant on only one farm. Of the farms tested, 55% ran meat breeds, 60% dosed more than the recommended dose rate and 70% always, mostly or when possible practised a ‘drench and move’ strategy. CONCLUSION: This level of anthelmintic resistance in southern Queensland will severely compromise worm control and force increased use of monepantel.</description><subject>abamectin</subject><subject>Animal Husbandry</subject><subject>Animals</subject><subject>anthelmintic resistance</subject><subject>Anthelmintics - pharmacology</subject><subject>breeds</subject><subject>closantel</subject><subject>Drug Resistance, Microbial - drug effects</subject><subject>eggs</subject><subject>faecal egg count reduction test</subject><subject>farmers</subject><subject>Farms</subject><subject>fecal egg count</subject><subject>feces</subject><subject>gastrointestinal nematodes</subject><subject>Haemonchus contortus</subject><subject>larvae</subject><subject>levamisole</subject><subject>meat</subject><subject>moxidectin</subject><subject>Nematoda - drug effects</subject><subject>nematode control</subject><subject>Nematode Infections - drug therapy</subject><subject>Nematode Infections - veterinary</subject><subject>Parasite Egg Count - veterinary</subject><subject>Queensland</subject><subject>questionnaires</subject><subject>Sheep</subject><subject>Sheep Diseases - drug therapy</subject><subject>Surveys and Questionnaires</subject><subject>Trichostrongylus colubriformis</subject><issn>0005-0423</issn><issn>1751-0813</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNpdkU9P3DAQxS1UVBbaQ79AG4kLl4DHjp3kuEJd_giBELQVJ8tJJtTbxKF2AuXbd3YXOOCLLc_vjebNY-wL8EOgc2Qfl4cghOJbbAa5gpQXID-wGedcpTwTcoftxrjkXOZKqI9sRyiZFZBlM3Y39-Nv7HrnR1cnAaOLo_U1Js4nw6PzmNzbOIaB6hhH522XeOztODQYV4zznfVNEoeJ2gSfXE-IPq7-PrHt1nYRP7_ce-x28f32-DS9uDo5O55fpK3MNU9BKwm65rKSomjLDAVXAlHkoGRhi6JuS1WWQJioGqlQQNVUtSBxIy3Wco8dbNo-hOHvRDOa3sUaOxoBhyka0EBOhZaS0P136HKYAllaU7rkZamAqK8v1FT12JiH4Hobns3rzgg42gBPrsPntzpwswrDUBhmHYaZ_zxfP0iRbhS0XPz3prDhj9E5ZWJ-XZ4YvVhcZlqDOSX-24Zv7WDsfXDR_LgRHBQFWkpOZv4Df7WTUg</recordid><startdate>201411</startdate><enddate>201411</enddate><creator>Lyndal‐Murphy, M</creator><creator>Ehrlich, WK</creator><creator>Mayer, DG</creator><general>Australian Veterinary Association</general><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9564-9176</orcidid></search><sort><creationdate>201411</creationdate><title>Anthelmintic resistance in ovine gastrointestinal nematodes in inland southern Queensland</title><author>Lyndal‐Murphy, M ; Ehrlich, WK ; Mayer, DG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f3760-165316c03b328f94e2052ee271538a88cf959911652bd35e21bdbc2f37d3aec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>abamectin</topic><topic>Animal Husbandry</topic><topic>Animals</topic><topic>anthelmintic resistance</topic><topic>Anthelmintics - pharmacology</topic><topic>breeds</topic><topic>closantel</topic><topic>Drug Resistance, Microbial - drug effects</topic><topic>eggs</topic><topic>faecal egg count reduction test</topic><topic>farmers</topic><topic>Farms</topic><topic>fecal egg count</topic><topic>feces</topic><topic>gastrointestinal nematodes</topic><topic>Haemonchus contortus</topic><topic>larvae</topic><topic>levamisole</topic><topic>meat</topic><topic>moxidectin</topic><topic>Nematoda - drug effects</topic><topic>nematode control</topic><topic>Nematode Infections - drug therapy</topic><topic>Nematode Infections - veterinary</topic><topic>Parasite Egg Count - veterinary</topic><topic>Queensland</topic><topic>questionnaires</topic><topic>Sheep</topic><topic>Sheep Diseases - drug therapy</topic><topic>Surveys and Questionnaires</topic><topic>Trichostrongylus colubriformis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lyndal‐Murphy, M</creatorcontrib><creatorcontrib>Ehrlich, WK</creatorcontrib><creatorcontrib>Mayer, DG</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Australian veterinary journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lyndal‐Murphy, M</au><au>Ehrlich, WK</au><au>Mayer, DG</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anthelmintic resistance in ovine gastrointestinal nematodes in inland southern Queensland</atitle><jtitle>Australian veterinary journal</jtitle><addtitle>Aust Vet J</addtitle><date>2014-11</date><risdate>2014</risdate><volume>92</volume><issue>11</issue><spage>415</spage><epage>420</epage><pages>415-420</pages><issn>0005-0423</issn><eissn>1751-0813</eissn><abstract>OBJECTIVE: To establish the prevalence of anthelmintic resistance in ovine gastrointestinal nematodes in southern Queensland. DESIGN: An observational parasitological study using the faecal egg count reduction test. METHODS: Sheep farms (n = 20) enrolled in this study met the twin criteria of using worm testing for drench decisions and having concerns about anthelmintic efficacy. On each farm, 105 sheep were randomly allocated to one of six treatment groups or an untreated control group. Faecal samples were collected on day 0 and days 10–14 for worm egg counts and larval differentiation. Single‐ and multi‐combination anthelmintics, persistent and non‐persistent, oral liquid or capsule, pour‐on and injectable formulations were tested. Monepantel was not tested. Farmers also responded to a questionnaire on drenching practices. RESULTS: Haemonchus contortus was the predominant species. Efficacy <95% was recorded on 85% of farms for one or more anthelmintics and on 10% of farms for six anthelmintics. No resistance was identified on three farms. The 4‐way combination product was efficacious (n = 4 farms). Napthalophos resistance was detected on one farm only. Resistance to levamisole (42% of farms), moxidectin injection (50% of farms) and the closantel/abamectin combination (67% of farms) was identified. Moxidectin oral was efficacious against Trichostrongylus colubriformis, which was predominant on only one farm. Of the farms tested, 55% ran meat breeds, 60% dosed more than the recommended dose rate and 70% always, mostly or when possible practised a ‘drench and move’ strategy. CONCLUSION: This level of anthelmintic resistance in southern Queensland will severely compromise worm control and force increased use of monepantel.</abstract><cop>England</cop><pub>Australian Veterinary Association</pub><pmid>25348144</pmid><doi>10.1111/avj.12250</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-9564-9176</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Australian veterinary journal, 2014-11, Vol.92 (11), p.415-420 |
| issn | 0005-0423 1751-0813 |
| language | eng |
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| subjects | abamectin Animal Husbandry Animals anthelmintic resistance Anthelmintics - pharmacology breeds closantel Drug Resistance, Microbial - drug effects eggs faecal egg count reduction test farmers Farms fecal egg count feces gastrointestinal nematodes Haemonchus contortus larvae levamisole meat moxidectin Nematoda - drug effects nematode control Nematode Infections - drug therapy Nematode Infections - veterinary Parasite Egg Count - veterinary Queensland questionnaires Sheep Sheep Diseases - drug therapy Surveys and Questionnaires Trichostrongylus colubriformis |
| title | Anthelmintic resistance in ovine gastrointestinal nematodes in inland southern Queensland |
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