Cytological diagnosis of angiosarcoma arising in an immunosuppressed patient 6 years after multi-visceral transplantation

Angiosarcoma is a rare and aggressive malignant tumor of soft tissue. It can arise in almost any part of the body, most commonly in the skin and the superficial soft tissue in the head and neck region. Although the etiology of angiosarcoma is unknown, there are several well‐known risk factors, such...

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Bibliographic Details
Published in:Diagnostic cytopathology 2014-10, Vol.42 (10), p.884-889
Main Authors: Chen, Xiaowei, Lagana, Stephen M., Poneros, John, Kato, Tomoaki, Remotti, Fabrizio, He, Huangjun, Kaminsky, Dmitry, Hamele-Bena, Diane
Format: Article
Language:English
Subjects:
angiosarcoma
ascites fluid
EUS-guided FNA
immunosuppression
multi-visceral transplantation
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Summary:Angiosarcoma is a rare and aggressive malignant tumor of soft tissue. It can arise in almost any part of the body, most commonly in the skin and the superficial soft tissue in the head and neck region. Although the etiology of angiosarcoma is unknown, there are several well‐known risk factors, such as chronic lymphedema, exposure to radiation, toxins, and foreign bodies. It rarely occurs in transplant patients. Cytological criteria for the diagnosis of angiosarcoma have not been fully established, having been described only in a few cases, mostly fine‐needle aspiration biopsies (FNAB). Herein, we present a case of angiosarcoma arising in an immunosuppressed patient status post multi‐visceral transplantation and diagnosed by cytology. To the best of our knowledge, this is the first report of such a case in the English literature. The cytological findings from endoscopic ultrasound‐guided FNAB and ascites fluid are discussed. Diagn. Cytopathol. 2014;42:884–889. © 2013 Wiley Periodicals, Inc.
ISSN:8755-1039
1097-0339
DOI:10.1002/dc.23068