Loading…

Zerumbone Suppresses IL‐1β‐induced Cell Migration and Invasion by Inhibiting IL‐8 and MMP‐3 Expression in Human Triple‐negative Breast Cancer Cells

Inflammation is a key regulatory process in cancer development. Prolonged exposure of breast tumor cells to inflammatory cytokines leads to epithelial‐mesenchymal transition, which is the principal mechanism involved in metastasis and tumor invasion. Interleukin (IL)‐1β is a major inflammatory cytok...

Full description

Saved in:
Bibliographic Details
Published in:Phytotherapy research 2014-11, Vol.28 (11), p.1654-1660
Main Authors: Han, Jeonghun, Bae, Soo Youn, Oh, Soo‐Jin, Lee, Jeongmin, Lee, Jun Ho, Lee, Hyun‐chul, Lee, Se Kyung, Kil, Won Ho, Kim, Seok Won, Nam, Seok Jin, Kim, Sangmin, Lee, Jeong Eon
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c4538-9b86c60836f008ae9a2bb2ee02ebddb0b8e846b1d0daa45f91de5278a80a7cc53
cites cdi_FETCH-LOGICAL-c4538-9b86c60836f008ae9a2bb2ee02ebddb0b8e846b1d0daa45f91de5278a80a7cc53
container_end_page 1660
container_issue 11
container_start_page 1654
container_title Phytotherapy research
container_volume 28
creator Han, Jeonghun
Bae, Soo Youn
Oh, Soo‐Jin
Lee, Jeongmin
Lee, Jun Ho
Lee, Hyun‐chul
Lee, Se Kyung
Kil, Won Ho
Kim, Seok Won
Nam, Seok Jin
Kim, Sangmin
Lee, Jeong Eon
description Inflammation is a key regulatory process in cancer development. Prolonged exposure of breast tumor cells to inflammatory cytokines leads to epithelial‐mesenchymal transition, which is the principal mechanism involved in metastasis and tumor invasion. Interleukin (IL)‐1β is a major inflammatory cytokine in a variety of tumors. To date, the regulatory mechanism of IL‐1β‐induced cell migration and invasion has not been fully elucidated. Here, we investigated the effect of zerumbone (ZER) on IL‐1β‐induced cell migration and invasion in breast cancer cells. The levels of IL‐8 and matrix metalloproteinase (MMP)‐3 mRNA were analyzed by real‐time polymerase chain reaction. The levels of secreted IL‐8 and MMP‐3 protein were analyzed by enzyme‐linked immunosorbent assay and western blot analysis, respectively. Cell invasion and migration was detected by Boyden chamber assay. The levels of IL‐8 and MMP‐3 expression were significantly increased by IL‐1β treatment in Hs578T and MDA‐MB231 cells. On the other hand, IL‐1β‐induced IL‐8 and MMP‐3 expression was decreased by ZER. Finally, IL‐1β‐induced cell migration and invasion were decreased by ZER in Hs578T and MDA‐MB231 cells. ZER suppresses IL‐1β‐induced cell migration and invasion by inhibiting IL‐8 expression and MMP‐3 expression in TNBC cells. ZER could be a promising therapeutic drug for treatment of triple‐negative breast cancer patients. Copyright © 2014 John Wiley & Sons, Ltd.
doi_str_mv 10.1002/ptr.5178
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1618154363</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1618154363</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4538-9b86c60836f008ae9a2bb2ee02ebddb0b8e846b1d0daa45f91de5278a80a7cc53</originalsourceid><addsrcrecordid>eNp1kk9u1DAUhy0EokNB4gTgJZsUO44Tewmj0o40AyM6ZapuLDt5MxgSJ9hJ6ew4AifgEByEQ3ASPH8oKzb2s_z5e5Z_RugpJSeUkPRl1_sTTgtxD40okTKhvGD30YhITpOMiqsj9CiET4QQmZLsITpKMyFJysUI_bgGPzSmdYAvhq7zEAIEPJn-_vad_voZR-uqoYQKj6Gu8cyuve5t67B2FZ64Gx22C7OJ9UdrbG_den9Y7IjZbB5rhk9vd-Ytax0-Hxrt8MLbroa47WAdnTeAX3vQocdj7Urwu4bhMXqw0nWAJ4f5GF2-OV2Mz5Ppu7PJ-NU0KTPORCKNyMucCJavCBEapE6NSQFICqaqDDECRJYbWpFK64yvJK2Ap4XQguiiLDk7Ri_23s63XwYIvWpsKOMNtIN2CIrmVFCesZz9Q0vfhuBhpTpvG-03ihK1TUPFNNQ2jYg-O1gH00B1B_59_ggke-CrrWHzX5GaL94fhAfehh5u73jtP6u8YAVXy7dnan51vZTzD0wtI_98z690q_Ta26AuL1JCefwKVGaUsz_EI7NZ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1618154363</pqid></control><display><type>article</type><title>Zerumbone Suppresses IL‐1β‐induced Cell Migration and Invasion by Inhibiting IL‐8 and MMP‐3 Expression in Human Triple‐negative Breast Cancer Cells</title><source>Wiley</source><creator>Han, Jeonghun ; Bae, Soo Youn ; Oh, Soo‐Jin ; Lee, Jeongmin ; Lee, Jun Ho ; Lee, Hyun‐chul ; Lee, Se Kyung ; Kil, Won Ho ; Kim, Seok Won ; Nam, Seok Jin ; Kim, Sangmin ; Lee, Jeong Eon</creator><creatorcontrib>Han, Jeonghun ; Bae, Soo Youn ; Oh, Soo‐Jin ; Lee, Jeongmin ; Lee, Jun Ho ; Lee, Hyun‐chul ; Lee, Se Kyung ; Kil, Won Ho ; Kim, Seok Won ; Nam, Seok Jin ; Kim, Sangmin ; Lee, Jeong Eon</creatorcontrib><description>Inflammation is a key regulatory process in cancer development. Prolonged exposure of breast tumor cells to inflammatory cytokines leads to epithelial‐mesenchymal transition, which is the principal mechanism involved in metastasis and tumor invasion. Interleukin (IL)‐1β is a major inflammatory cytokine in a variety of tumors. To date, the regulatory mechanism of IL‐1β‐induced cell migration and invasion has not been fully elucidated. Here, we investigated the effect of zerumbone (ZER) on IL‐1β‐induced cell migration and invasion in breast cancer cells. The levels of IL‐8 and matrix metalloproteinase (MMP)‐3 mRNA were analyzed by real‐time polymerase chain reaction. The levels of secreted IL‐8 and MMP‐3 protein were analyzed by enzyme‐linked immunosorbent assay and western blot analysis, respectively. Cell invasion and migration was detected by Boyden chamber assay. The levels of IL‐8 and MMP‐3 expression were significantly increased by IL‐1β treatment in Hs578T and MDA‐MB231 cells. On the other hand, IL‐1β‐induced IL‐8 and MMP‐3 expression was decreased by ZER. Finally, IL‐1β‐induced cell migration and invasion were decreased by ZER in Hs578T and MDA‐MB231 cells. ZER suppresses IL‐1β‐induced cell migration and invasion by inhibiting IL‐8 expression and MMP‐3 expression in TNBC cells. ZER could be a promising therapeutic drug for treatment of triple‐negative breast cancer patients. Copyright © 2014 John Wiley &amp; Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.5178</identifier><identifier>PMID: 24890258</identifier><language>eng</language><publisher>England: Heyden &amp; Son</publisher><subject>breast neoplasms ; cell invasion ; Cell Line, Tumor ; cell movement ; Cell Movement - drug effects ; drug therapy ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; IL-1β ; IL-8 ; inflammation ; interleukin-1beta ; Interleukin-1beta - pharmacology ; Interleukin-8 - metabolism ; Matrix Metalloproteinase 3 - metabolism ; messenger RNA ; metastasis ; MMP-3 ; Neoplasm Invasiveness ; patients ; polymerase chain reaction ; Sesquiterpenes - pharmacology ; Triple Negative Breast Neoplasms - metabolism ; Triple Negative Breast Neoplasms - pathology ; triple-negative breast cancer ; Western blotting ; zerumbone</subject><ispartof>Phytotherapy research, 2014-11, Vol.28 (11), p.1654-1660</ispartof><rights>Copyright © 2014 John Wiley &amp; Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4538-9b86c60836f008ae9a2bb2ee02ebddb0b8e846b1d0daa45f91de5278a80a7cc53</citedby><cites>FETCH-LOGICAL-c4538-9b86c60836f008ae9a2bb2ee02ebddb0b8e846b1d0daa45f91de5278a80a7cc53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24890258$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Han, Jeonghun</creatorcontrib><creatorcontrib>Bae, Soo Youn</creatorcontrib><creatorcontrib>Oh, Soo‐Jin</creatorcontrib><creatorcontrib>Lee, Jeongmin</creatorcontrib><creatorcontrib>Lee, Jun Ho</creatorcontrib><creatorcontrib>Lee, Hyun‐chul</creatorcontrib><creatorcontrib>Lee, Se Kyung</creatorcontrib><creatorcontrib>Kil, Won Ho</creatorcontrib><creatorcontrib>Kim, Seok Won</creatorcontrib><creatorcontrib>Nam, Seok Jin</creatorcontrib><creatorcontrib>Kim, Sangmin</creatorcontrib><creatorcontrib>Lee, Jeong Eon</creatorcontrib><title>Zerumbone Suppresses IL‐1β‐induced Cell Migration and Invasion by Inhibiting IL‐8 and MMP‐3 Expression in Human Triple‐negative Breast Cancer Cells</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>Inflammation is a key regulatory process in cancer development. Prolonged exposure of breast tumor cells to inflammatory cytokines leads to epithelial‐mesenchymal transition, which is the principal mechanism involved in metastasis and tumor invasion. Interleukin (IL)‐1β is a major inflammatory cytokine in a variety of tumors. To date, the regulatory mechanism of IL‐1β‐induced cell migration and invasion has not been fully elucidated. Here, we investigated the effect of zerumbone (ZER) on IL‐1β‐induced cell migration and invasion in breast cancer cells. The levels of IL‐8 and matrix metalloproteinase (MMP)‐3 mRNA were analyzed by real‐time polymerase chain reaction. The levels of secreted IL‐8 and MMP‐3 protein were analyzed by enzyme‐linked immunosorbent assay and western blot analysis, respectively. Cell invasion and migration was detected by Boyden chamber assay. The levels of IL‐8 and MMP‐3 expression were significantly increased by IL‐1β treatment in Hs578T and MDA‐MB231 cells. On the other hand, IL‐1β‐induced IL‐8 and MMP‐3 expression was decreased by ZER. Finally, IL‐1β‐induced cell migration and invasion were decreased by ZER in Hs578T and MDA‐MB231 cells. ZER suppresses IL‐1β‐induced cell migration and invasion by inhibiting IL‐8 expression and MMP‐3 expression in TNBC cells. ZER could be a promising therapeutic drug for treatment of triple‐negative breast cancer patients. Copyright © 2014 John Wiley &amp; Sons, Ltd.</description><subject>breast neoplasms</subject><subject>cell invasion</subject><subject>Cell Line, Tumor</subject><subject>cell movement</subject><subject>Cell Movement - drug effects</subject><subject>drug therapy</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>IL-1β</subject><subject>IL-8</subject><subject>inflammation</subject><subject>interleukin-1beta</subject><subject>Interleukin-1beta - pharmacology</subject><subject>Interleukin-8 - metabolism</subject><subject>Matrix Metalloproteinase 3 - metabolism</subject><subject>messenger RNA</subject><subject>metastasis</subject><subject>MMP-3</subject><subject>Neoplasm Invasiveness</subject><subject>patients</subject><subject>polymerase chain reaction</subject><subject>Sesquiterpenes - pharmacology</subject><subject>Triple Negative Breast Neoplasms - metabolism</subject><subject>Triple Negative Breast Neoplasms - pathology</subject><subject>triple-negative breast cancer</subject><subject>Western blotting</subject><subject>zerumbone</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp1kk9u1DAUhy0EokNB4gTgJZsUO44Tewmj0o40AyM6ZapuLDt5MxgSJ9hJ6ew4AifgEByEQ3ASPH8oKzb2s_z5e5Z_RugpJSeUkPRl1_sTTgtxD40okTKhvGD30YhITpOMiqsj9CiET4QQmZLsITpKMyFJysUI_bgGPzSmdYAvhq7zEAIEPJn-_vad_voZR-uqoYQKj6Gu8cyuve5t67B2FZ64Gx22C7OJ9UdrbG_den9Y7IjZbB5rhk9vd-Ytax0-Hxrt8MLbroa47WAdnTeAX3vQocdj7Urwu4bhMXqw0nWAJ4f5GF2-OV2Mz5Ppu7PJ-NU0KTPORCKNyMucCJavCBEapE6NSQFICqaqDDECRJYbWpFK64yvJK2Ap4XQguiiLDk7Ri_23s63XwYIvWpsKOMNtIN2CIrmVFCesZz9Q0vfhuBhpTpvG-03ihK1TUPFNNQ2jYg-O1gH00B1B_59_ggke-CrrWHzX5GaL94fhAfehh5u73jtP6u8YAVXy7dnan51vZTzD0wtI_98z690q_Ta26AuL1JCefwKVGaUsz_EI7NZ</recordid><startdate>201411</startdate><enddate>201411</enddate><creator>Han, Jeonghun</creator><creator>Bae, Soo Youn</creator><creator>Oh, Soo‐Jin</creator><creator>Lee, Jeongmin</creator><creator>Lee, Jun Ho</creator><creator>Lee, Hyun‐chul</creator><creator>Lee, Se Kyung</creator><creator>Kil, Won Ho</creator><creator>Kim, Seok Won</creator><creator>Nam, Seok Jin</creator><creator>Kim, Sangmin</creator><creator>Lee, Jeong Eon</creator><general>Heyden &amp; Son</general><general>Blackwell Publishing Ltd</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201411</creationdate><title>Zerumbone Suppresses IL‐1β‐induced Cell Migration and Invasion by Inhibiting IL‐8 and MMP‐3 Expression in Human Triple‐negative Breast Cancer Cells</title><author>Han, Jeonghun ; Bae, Soo Youn ; Oh, Soo‐Jin ; Lee, Jeongmin ; Lee, Jun Ho ; Lee, Hyun‐chul ; Lee, Se Kyung ; Kil, Won Ho ; Kim, Seok Won ; Nam, Seok Jin ; Kim, Sangmin ; Lee, Jeong Eon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4538-9b86c60836f008ae9a2bb2ee02ebddb0b8e846b1d0daa45f91de5278a80a7cc53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>breast neoplasms</topic><topic>cell invasion</topic><topic>Cell Line, Tumor</topic><topic>cell movement</topic><topic>Cell Movement - drug effects</topic><topic>drug therapy</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>IL-1β</topic><topic>IL-8</topic><topic>inflammation</topic><topic>interleukin-1beta</topic><topic>Interleukin-1beta - pharmacology</topic><topic>Interleukin-8 - metabolism</topic><topic>Matrix Metalloproteinase 3 - metabolism</topic><topic>messenger RNA</topic><topic>metastasis</topic><topic>MMP-3</topic><topic>Neoplasm Invasiveness</topic><topic>patients</topic><topic>polymerase chain reaction</topic><topic>Sesquiterpenes - pharmacology</topic><topic>Triple Negative Breast Neoplasms - metabolism</topic><topic>Triple Negative Breast Neoplasms - pathology</topic><topic>triple-negative breast cancer</topic><topic>Western blotting</topic><topic>zerumbone</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Han, Jeonghun</creatorcontrib><creatorcontrib>Bae, Soo Youn</creatorcontrib><creatorcontrib>Oh, Soo‐Jin</creatorcontrib><creatorcontrib>Lee, Jeongmin</creatorcontrib><creatorcontrib>Lee, Jun Ho</creatorcontrib><creatorcontrib>Lee, Hyun‐chul</creatorcontrib><creatorcontrib>Lee, Se Kyung</creatorcontrib><creatorcontrib>Kil, Won Ho</creatorcontrib><creatorcontrib>Kim, Seok Won</creatorcontrib><creatorcontrib>Nam, Seok Jin</creatorcontrib><creatorcontrib>Kim, Sangmin</creatorcontrib><creatorcontrib>Lee, Jeong Eon</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Han, Jeonghun</au><au>Bae, Soo Youn</au><au>Oh, Soo‐Jin</au><au>Lee, Jeongmin</au><au>Lee, Jun Ho</au><au>Lee, Hyun‐chul</au><au>Lee, Se Kyung</au><au>Kil, Won Ho</au><au>Kim, Seok Won</au><au>Nam, Seok Jin</au><au>Kim, Sangmin</au><au>Lee, Jeong Eon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Zerumbone Suppresses IL‐1β‐induced Cell Migration and Invasion by Inhibiting IL‐8 and MMP‐3 Expression in Human Triple‐negative Breast Cancer Cells</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. Res</addtitle><date>2014-11</date><risdate>2014</risdate><volume>28</volume><issue>11</issue><spage>1654</spage><epage>1660</epage><pages>1654-1660</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>Inflammation is a key regulatory process in cancer development. Prolonged exposure of breast tumor cells to inflammatory cytokines leads to epithelial‐mesenchymal transition, which is the principal mechanism involved in metastasis and tumor invasion. Interleukin (IL)‐1β is a major inflammatory cytokine in a variety of tumors. To date, the regulatory mechanism of IL‐1β‐induced cell migration and invasion has not been fully elucidated. Here, we investigated the effect of zerumbone (ZER) on IL‐1β‐induced cell migration and invasion in breast cancer cells. The levels of IL‐8 and matrix metalloproteinase (MMP)‐3 mRNA were analyzed by real‐time polymerase chain reaction. The levels of secreted IL‐8 and MMP‐3 protein were analyzed by enzyme‐linked immunosorbent assay and western blot analysis, respectively. Cell invasion and migration was detected by Boyden chamber assay. The levels of IL‐8 and MMP‐3 expression were significantly increased by IL‐1β treatment in Hs578T and MDA‐MB231 cells. On the other hand, IL‐1β‐induced IL‐8 and MMP‐3 expression was decreased by ZER. Finally, IL‐1β‐induced cell migration and invasion were decreased by ZER in Hs578T and MDA‐MB231 cells. ZER suppresses IL‐1β‐induced cell migration and invasion by inhibiting IL‐8 expression and MMP‐3 expression in TNBC cells. ZER could be a promising therapeutic drug for treatment of triple‐negative breast cancer patients. Copyright © 2014 John Wiley &amp; Sons, Ltd.</abstract><cop>England</cop><pub>Heyden &amp; Son</pub><pmid>24890258</pmid><doi>10.1002/ptr.5178</doi><tpages>7</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0951-418X
ispartof Phytotherapy research, 2014-11, Vol.28 (11), p.1654-1660
issn 0951-418X
1099-1573
language eng
recordid cdi_proquest_miscellaneous_1618154363
source Wiley
subjects breast neoplasms
cell invasion
Cell Line, Tumor
cell movement
Cell Movement - drug effects
drug therapy
Female
Gene Expression Regulation, Neoplastic
Humans
IL-1β
IL-8
inflammation
interleukin-1beta
Interleukin-1beta - pharmacology
Interleukin-8 - metabolism
Matrix Metalloproteinase 3 - metabolism
messenger RNA
metastasis
MMP-3
Neoplasm Invasiveness
patients
polymerase chain reaction
Sesquiterpenes - pharmacology
Triple Negative Breast Neoplasms - metabolism
Triple Negative Breast Neoplasms - pathology
triple-negative breast cancer
Western blotting
zerumbone
title Zerumbone Suppresses IL‐1β‐induced Cell Migration and Invasion by Inhibiting IL‐8 and MMP‐3 Expression in Human Triple‐negative Breast Cancer Cells
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T15%3A27%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Zerumbone%20Suppresses%20IL%E2%80%901%CE%B2%E2%80%90induced%20Cell%20Migration%20and%20Invasion%20by%20Inhibiting%20IL%E2%80%908%20and%20MMP%E2%80%903%20Expression%20in%20Human%20Triple%E2%80%90negative%20Breast%20Cancer%20Cells&rft.jtitle=Phytotherapy%20research&rft.au=Han,%20Jeonghun&rft.date=2014-11&rft.volume=28&rft.issue=11&rft.spage=1654&rft.epage=1660&rft.pages=1654-1660&rft.issn=0951-418X&rft.eissn=1099-1573&rft_id=info:doi/10.1002/ptr.5178&rft_dat=%3Cproquest_cross%3E1618154363%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4538-9b86c60836f008ae9a2bb2ee02ebddb0b8e846b1d0daa45f91de5278a80a7cc53%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1618154363&rft_id=info:pmid/24890258&rfr_iscdi=true