Review of the Pharmacological Effects of Piceatannol on Cardiovascular Diseases

The incidence of cardiovascular diseases (CVDs) is high in both developed and developing countries. It has a high global rate of mortality and causes heavy social burden. Drugs are available for managing or treating CVDs and its complications. Consumption of dietary supplements or functional foods f...

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Bibliographic Details
Published in:Phytotherapy research 2014-11, Vol.28 (11), p.1581-1588
Main Authors: Tang, Yee‐Ling, Chan, Shun‐Wan
Format: Article
Language:English
Subjects:
angiogenesis
Animals
antioxidant activity
arrhythmia
atherosclerosis
bioavailability
cardiovascular diseases
Cardiovascular Diseases - drug therapy
cardiovascular system
developing countries
dietary supplements
drugs
functional foods
Humans
hypercholesterolemia
metabolites
mortality
piceatannol
resveratrol
risk
stilbene
Stilbenes - pharmacology
therapeutics
vasodilation
wine grapes
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Summary:The incidence of cardiovascular diseases (CVDs) is high in both developed and developing countries. It has a high global rate of mortality and causes heavy social burden. Drugs are available for managing or treating CVDs and its complications. Consumption of dietary supplements or functional foods for reducing the risk of CVDs has also gained wide recognition by the general public. Piceatannol, an analog and metabolite of resveratrol, is a natural stilbene commonly found in the skin of grapes and wine. Piceatannol is believed to be a potent compound with certain cardiovascular therapeutic effects, such as the prevention of hypercholesterolemia, arrhythmia, atherosclerosis, and angiogenesis. It also has vasorelaxation and antioxidant activities. A comprehensive review of piceatannol concludes that piceatannol has the potential to be developed into health products for the cardiovascular system to help modern society reduce the high CVD incidence. However, further investigations are warranted in order to increase the bioavailability and understand the biological mechanisms and safety of using piceatannol. Copyright © 2014 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.5185