Oxytocin improves behavioural and neural deficits in inferring others' social emotions in autism

• Published in: Brain (London, England : 1878) England : 1878), 2014-11, Vol.137 (Pt 11), p.3073-3086
• Main Authors: AOKI, Yuta, YAHATA, Noriaki, TAKAO, Hidemasa, SASAKI, Hiroki, GONOI, Wataru, KUNIMATSU, Akira, KASAI, Kiyoto, YAMASUE, Hidenori, WATANABE, Takamitsu, TAKANO, Yosuke, KAWAKUBO, Yuki, KUWABARA, Hitoshi, IWASHIRO, Norichika, NATSUBORI, Tatsunobu, INOUE, Hideyuki, SUGA, Motomu
• Format: Article
• Language: English
• Subjects: Adult; Attention deficit disorders. Hyperactivity; Biological and medical sciences; Case-Control Studies; Cerebral Cortex - drug effects; Cerebral Cortex - physiopathology; Child clinical studies; Child Development Disorders, Pervasive - drug therapy; Child Development Disorders, Pervasive - physiopathology; Cross-Over Studies; Developmental disorders; Double-Blind Method; Emotions - physiology; Empathy - drug effects; Empathy - physiology; Facial Expression; Functional Neuroimaging; Humans; Infantile autism; Magnetic Resonance Imaging; Male; Medical sciences; Neurology; Oxytocin - administration & dosage; Oxytocin - pharmacology; Placebos; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Social Perception; Theory of Mind - drug effects; Theory of Mind - physiology; Treatment Outcome; Young Adult
• ISSN: 0006-8950; 1460-2156
• DOI: 10.1093/brain/awu231

Recent studies have suggested oxytocin's therapeutic effects on deficits in social communication and interaction in autism spectrum disorder through improvement of emotion recognition with direct emotional cues, such as facial expression and voice prosody. Although difficulty in understanding of others' social emotions and beliefs under conditions without direct emotional cues also plays an important role in autism spectrum disorder, no study has examined the potential effect of oxytocin on this difficulty. Here, we sequentially conducted both a case-control study and a clinical trial to investigate the potential effects of oxytocin on this difficulty at behavioural and neural levels measured using functional magnetic resonance imaging during a psychological task. This task was modified from the Sally-Anne Task, a well-known first-order false belief task. The task was optimized for investigation of the abilities to infer another person's social emotions and beliefs distinctively so as to test the hypothesis that oxytocin improves deficit in inferring others' social emotions rather than beliefs, under conditions without direct emotional cues. In the case-control study, 17 males with autism spectrum disorder showed significant behavioural deficits in inferring others' social emotions (P = 0.018) but not in inferring others' beliefs (P = 0.064) compared with 17 typically developing demographically-matched male participants. They also showed significantly less activity in the right anterior insula and posterior superior temporal sulcus during inferring others' social emotions, and in the dorsomedial prefrontal cortex during inferring others' beliefs compared with the typically developing participants (P < 0.001 and cluster size > 10 voxels). Then, to investigate potential effects of oxytocin on these behavioural and neural deficits, we conducted a double-blind placebo-controlled crossover within-subject trial for single-dose intranasal administration of 24 IU oxytocin in an independent group of 20 males with autism spectrum disorder. Behaviourally, oxytocin significantly increased the correct rate in inferring others' social emotions (P = 0.043, one-tail). At the neural level, the peptide significantly enhanced the originally-diminished brain activity in the right anterior insula during inferring others' social emotions (P = 0.004), but not in the dorsomedial prefrontal cortex during inferring others' beliefs (P = 0.858). The present findings suggest that oxyt