Utility of finger maze test for learning and memory abilities in infants of cynomolgus monkeys exposed to thiamazole

A new type of learning and memory test using a finger maze was conducted in infant cynomolgus monkeys that were exposed to thiamazole (2 and 3.5 mg/kg per day to pregnant animals orally) during the fetal period (gestational days 120 to 150). We modified Tsuchida's original finger maze test meth...

Full description

Saved in:
Bibliographic Details
Published in:Congenital anomalies 2014-11, Vol.54 (4), p.220-224
Main Authors: Inoue, Ayumi, Arima, Akihiro, Kato, Hirohito, Ebihara, Shizufumi
Format: Article
Language:English
Subjects:
Animals
Behavior, Animal - drug effects
Brain
cynomolgus monkey
Female
finger maze
infant
learning and memory test
Macaca fascicularis - physiology
Male
Maze Learning - drug effects
Maze Learning - physiology
Memory - drug effects
Memory - physiology
Methimazole - administration & dosage
Pregnancy
Prenatal Exposure Delayed Effects
Short term
thiamazole
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A new type of learning and memory test using a finger maze was conducted in infant cynomolgus monkeys that were exposed to thiamazole (2 and 3.5 mg/kg per day to pregnant animals orally) during the fetal period (gestational days 120 to 150). We modified Tsuchida's original finger maze test method by reducing the number of trials per day and simplifying the criteria for achievement of training, and we added a long‐term memory test. In the memory test, thiamazole‐exposed infants required greater time to complete the finger maze test than the control infants although no effect was noted in the training or learning test. The results suggest that an impaired long‐term memory could be detected by our modified finger maze test.
ISSN:0914-3505
1741-4520
DOI:10.1111/cga.12068