The gene responsible for X-linked cleft palate (CPX) in a British Columbia native kindred is localized between PGKI and DXYSI

We have undertaken a series of experiments directed toward the isolation of a gene involved in human secondary palate formation. DNA marker linkage studies have been performed in a large British Columbia (B.C.) Native family in which cleft palate segregates as an X-linked trait. We have examined 62...

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Bibliographic Details
Published in:American journal of human genetics 1992, Vol.50 (5), p.1129-1136
Main Authors: GORSKI, S. M, ADAMS, K. J, BIRCH, P. H, FRIEDMAN, J. M, GOODFELLOW, P. J
Format: Article
Language:English
Subjects:
Biological and medical sciences
Facial bones, jaws, teeth, parodontium: diseases, semeiology
genes
Medical sciences
Non tumoral diseases
Otorhinolaryngology. Stomatology
X chromosome
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Summary:We have undertaken a series of experiments directed toward the isolation of a gene involved in human secondary palate formation. DNA marker linkage studies have been performed in a large British Columbia (B.C.) Native family in which cleft palate segregates as an X-linked trait. We have examined 62 family members, including 15 affected males and 8 obligate carrier females. For the B.C. kindred reported here, we have mapped the gene responsible for cleft palate and/or ankyloglossia to a more proximal position on the X chromosome.
ISSN:0002-9297
1537-6605