The predicted translation product of a cardiac AE3 mRNA contains an N terminus distinct from that of the brain AE3 Cl super(-)/HCO sub(3) super(-) exchanger: Cloning of a cardiac AE3 cDNA organization of the AE3 gene, and identification of an alternative transcription initiation site

We have isolated cDNAs encoding a cardiac variant of the AE3 Cl super(-)/HCO sub(3) super(-) exchanger from a rat heart library. The predicted cardiac AE3 polypeptide is 1030 amino acids in length, while the AE3 variant expressed in brain consists of 1227 amino acids. Alternative promoter and exon u...

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Bibliographic Details
Published in:The Journal of biological chemistry 1992-01, Vol.267 (11), p.7927-7935
Main Authors: Linn, S C, Kudrycki, KE, Shull, GE
Format: Article
Language:English
Subjects:
Cl super(-)/HCO sub super(-) exchanger
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Summary:We have isolated cDNAs encoding a cardiac variant of the AE3 Cl super(-)/HCO sub(3) super(-) exchanger from a rat heart library. The predicted cardiac AE3 polypeptide is 1030 amino acids in length, while the AE3 variant expressed in brain consists of 1227 amino acids. Alternative promoter and exon usage are involved in generation of the two AE3 mRNAs.
ISSN:0021-9258