Gusperimus: immunological mechanism and clinical applications

Gusperimus is an immunosuppressive drug with a unique mode of action. We review its effects on different arms of the immune system and the current evidence for clinical applications, particularly in the treatment of transplant rejection and ANCA-associated vasculitis.

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Bibliographic Details
Published in:Rheumatology (Oxford, England) England), 2014-10, Vol.53 (10), p.1732-1741
Main Authors: Perenyei, Miklos, Jayne, David R W, Floßmann, Oliver
Format: Article
Language:English
Subjects:
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - drug therapy
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - immunology
Graft Rejection - drug therapy
Graft Rejection - immunology
Guanidines - pharmacology
Guanidines - therapeutic use
Humans
Immunosuppressive Agents - pharmacology
Immunosuppressive Agents - therapeutic use
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Description
Summary:Gusperimus is an immunosuppressive drug with a unique mode of action. We review its effects on different arms of the immune system and the current evidence for clinical applications, particularly in the treatment of transplant rejection and ANCA-associated vasculitis.
ISSN:1462-0324
1462-0332
DOI:10.1093/rheumatology/ket451