Regulation of vascular endothelial growth factor by metabolic context of the cell

Expression of vascular endothelial growth factor, major endothelial specific glycoprotein growth factor that promotes angiogenesis is regulated at transcriptional, post transcriptional and posttranslational levels. One of the key posttranslational modifications involved in regulating the angiogenic...

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Bibliographic Details
Published in:Glycoconjugate journal 2014-10, Vol.31 (6-7), p.427-434
Main Authors: Kumar, V. B. Sameer, Binu, S., Soumya, S. J., K., Haritha, Sudhakaran, P. R.
Format: Article
Language:English
Subjects:
Angiogenesis
Biochemistry
Biomedical and Life Sciences
Cellular biology
Life Sciences
Metabolites
Pathology
Poly Adenosine Diphosphate Ribose - metabolism
Unfolded Protein Response
Vascular endothelial growth factor
Vascular Endothelial Growth Factor A - metabolism
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Summary:Expression of vascular endothelial growth factor, major endothelial specific glycoprotein growth factor that promotes angiogenesis is regulated at transcriptional, post transcriptional and posttranslational levels. One of the key posttranslational modifications involved in regulating the angiogenic potential of VEGF is covalent modification involving polyADP ribosylation. Major factors contributing to the regulation of VEGF include factors relating to hypoxia, growth factors and cytokines and hormones. Apart from these, the metabolite status of the cell as sensed by various metabolite regulators can influence the angiogenic potential. Changes in the metabolite status of the cell occur during different conditions associated with excessive or insufficient angiogenesis contributing to pathology. Effect of metabolites, as exemplified by certain metabolites such as lactate, citrate, sarcosine, metabolites of arachidonic acid on angiogenesis through the regulation of expression of VEGF as well as its angiogenic potential through polyADP ribosylation is discussed.
ISSN:0282-0080
1573-4986
DOI:10.1007/s10719-014-9547-5