Experimental Investigation of Pharmacodynamics and Pharmacokinetics of Carbamazepine Nanoemulsion

Anticonvulsant activity and pharmacokinetics of nanoemulsion and unmodified substance of carbamazepine were compared in experiments on mice. Carbamazepine nanoemulsion demonstrated significant anticonvulsant activity and was superior to unmodified substance of carbamazepine against seizures induced...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2014-10, Vol.157 (6), p.742-746
Main Authors: Prokhorov, D. I., Sariev, A. K., Abramov, D. A., Voronina, T. A., Kapitsa, I. G., Zhuravko, A. S., Shiriaeva, M. V., Kaplun, A. P., Seifulla, R. D.
Format: Article
Language:English
Subjects:
Animals
Anticonvulsants - pharmacokinetics
Anticonvulsants - pharmacology
Biological Availability
Biomedical and Life Sciences
Biomedicine
Blood-Brain Barrier - metabolism
Carbamazepine
Cell Biology
Diethylcarbamazine - administration & dosage
Diethylcarbamazine - pharmacokinetics
Diethylcarbamazine - pharmacology
Electric Stimulation
Emulsions - administration & dosage
Emulsions - pharmacokinetics
Emulsions - pharmacology
Epilepsy
Internal Medicine
Laboratory Medicine
Male
Mice
Nanostructures - administration & dosage
Pathology
Picrotoxin - toxicity
Seizures (Medicine)
Seizures - chemically induced
Seizures - drug therapy
Statistics, Nonparametric
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Summary:Anticonvulsant activity and pharmacokinetics of nanoemulsion and unmodified substance of carbamazepine were compared in experiments on mice. Carbamazepine nanoemulsion demonstrated significant anticonvulsant activity and was superior to unmodified substance of carbamazepine against seizures induced by maximum electric shock and picrotoxin. Relative bioavailability of carbamazepine after administration of nanoemulsion was 160% compared to unmodified substance. Carbamazepine nanoemulsion more effectively penetrated through BBB by 1.5 times in comparison with unmodified substance.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-014-2657-z