Imaging of Site Specific Bone Turnover in Osteoporosis Using Positron Emission Tomography

The functional imaging technique of dynamic fluorine-18 labeled sodium fluoride positron emission tomography ( 18 F-NaF PET) allows the quantitative assessment of regional bone formation by measuring the plasma clearance of fluoride to bone at any site in the skeleton. 18 F-NaF PET provides a novel...

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Bibliographic Details
Published in:Current osteoporosis reports 2014-12, Vol.12 (4), p.475-485
Main Authors: Blake, Glen M., Siddique, Musib, Frost, Michelle L., Moore, Amelia E. B., Fogelman, Ignac
Format: Article
Language:English
Subjects:
Bone and Bones - metabolism
Diagnostic Imaging
Epidemiology
Fluorine Radioisotopes
Humans
Imaging (T Lang and F Wehrli
Mathematical Computing
Medicine
Medicine & Public Health
Orthopedics
Osteogenesis
Osteoporosis - diagnostic imaging
Osteoporosis - metabolism
Positron-Emission Tomography - methods
Section Editors
Time Factors
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Summary:The functional imaging technique of dynamic fluorine-18 labeled sodium fluoride positron emission tomography ( 18 F-NaF PET) allows the quantitative assessment of regional bone formation by measuring the plasma clearance of fluoride to bone at any site in the skeleton. 18 F-NaF PET provides a novel and noninvasive method of studying site-specific bone formation at the hip and spine, as well as areas of pure cortical or trabecular bone. The technique complements conventional measurements of bone turnover using biochemical markers and bone biopsy as a tool to investigate new treatments for osteoporosis, and holds promise of a future role as an early biomarker of treatment efficacy in clinical trials. This article reviews methods of acquiring and analyzing 18 F-NaF PET scan data, and outlines a simplified approach that uses 5-minute static PET scan images combined with venous blood samples to estimate 18 F-NaF plasma clearance at multiple sites in the skeleton with a single injection of tracer.
ISSN:1544-1873
1544-2241
DOI:10.1007/s11914-014-0231-2