A simple and rapid approach to evaluate the in vitro in vivo role of release controlling agent ethyl cellulose ether derivative polymer

Diclofenac sodium (DCL-Na) conventional oral tablets exhibit serious side effects when given for a longer period leading to noncompliance. Controlled release matrix tablets of diclofenac sodium were formulated using simple blending (F-1), solvent evaporation (F-2) and co-precipitation techniques (F-...

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Bibliographic Details
Published in:Pakistan journal of pharmaceutical sciences 2014-11, Vol.27 (6), p.1789-1798
Main Authors: Akhlaq, Muhammad, Khan, Gul Majid, Jan, Syed Umer, Wahab, Abdul, Hussain, Abid, Nawaz, Asif, Abdelkader, Hamdy
Format: Article
Language:English
Subjects:
Animals
Cellulose - analogs & derivatives
Cellulose - chemistry
Chemistry, Pharmaceutical
Delayed-Action Preparations
Diclofenac
Diclofenac - administration & dosage
Diclofenac - chemistry
Dosage and administration
Ethers
Male
Pharmacology
Polymers - chemistry
Polymers - pharmacokinetics
Rabbits
Solubility
Tablets
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Summary:Diclofenac sodium (DCL-Na) conventional oral tablets exhibit serious side effects when given for a longer period leading to noncompliance. Controlled release matrix tablets of diclofenac sodium were formulated using simple blending (F-1), solvent evaporation (F-2) and co-precipitation techniques (F-3). Ethocel® Standard 7 FP Premium Polymer (15%) was used as a release controlling agent. Drug release study was conducted in 7.4 pH phosphate buffer solutions as dissolution medium in vitro. Pharmacokinetic parameters were evaluated using albino rabbits. Solvent evaporation technique was found to be the best release controlling technique thereby prolonging the release rate up to 24 hours. Accelerated stability studies of the optimized test formulation (F-2) did not show any significant change (p
ISSN:1011-601X