Chitosan-poly (lactide-co-glycolide) (CS-PLGA) nanoparticles containing metformin HCl: preparation and in vitro evaluation

In this study, the preparation and in vitro characterisation of metformin HCl-loaded CS-PLGA nanoparticles (NPs) were aimed. The prepared nanoparticles (blank nanoparticles (C-1), 50 mg of metformin HCl loaded nanoparticles (C-2) and 75 mg of metformin HCl loaded nanoparticles (C-3) ranged in size f...

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Bibliographic Details
Published in:Pakistan journal of pharmaceutical sciences 2014-11, Vol.27 (6), p.1923-1929
Main Authors: Gundogdu, Nuran, Cetin, Meltem
Format: Article
Language:English
Subjects:
Analysis
Calorimetry, Differential Scanning
Chemical properties
Chemistry, Pharmaceutical
Chitin
Chitosan - chemistry
Health aspects
Hydrogen chloride
Lactic Acid - chemistry
Metformin
Metformin - chemistry
Nanoparticles - chemistry
Polyglycolic Acid - chemistry
Solubility
Spectroscopy, Fourier Transform Infrared
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Summary:In this study, the preparation and in vitro characterisation of metformin HCl-loaded CS-PLGA nanoparticles (NPs) were aimed. The prepared nanoparticles (blank nanoparticles (C-1), 50 mg of metformin HCl loaded nanoparticles (C-2) and 75 mg of metformin HCl loaded nanoparticles (C-3) ranged in size from 506.67±13.61 to 516.33±16.85 nm and had surface charges of 22.57±1.21 to 32.37±0.57 mV. Low encapsulation efficiency was observed for both nanoparticle formulations due to the leakage of metformin HCl to the external medium during preparation of nanoparticles. Nanoparticle formulations showed highly reproducible drug release profiles. ~20% of metformin HCl was released within 30 minutes and approximately 98% of the loaded metformin HCl was released at 144 hours in a phosphate buffer (PB; pH 6.8). No statistically significant difference was noted between the in vitro release profiles of the nanoparticles (C-2 and C-3) containing metformin HCl. Also, nanoparticles were characterised using FT-IR and DSC.
ISSN:1011-601X