Development of a Simple and Fast Electrochemical Method for Screening and Stoichiometric Determination of Dimenhydrinate

Dimenhydrinate (DIM) is a salt composed by the combination of two active pharmaceutical ingredients: diphenhydramine (DIP) and 8‐chlorotheophylline (CTP). In this work, the use of batch injection analysis with multiple pulse amperometric detection (BIA‐MPA) was proposed for the first time for fast s...

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Bibliographic Details
Published in:Electroanalysis (New York, N.Y.) N.Y.), 2014-09, Vol.26 (9), p.1905-1911
Main Authors: Machado Freitas, Jhonys, da Costa Oliveira, Thiago, Silva, Polyana Luiza, Tofanello Gimenes, Denise, Abarza Munoz, Rodrigo Alejandro, Richter, Eduardo Mathias
Format: Article
Language:English
Subjects:
8-Chlorotheophylline
Boron-doped diamond electrode
Calibration
Dimenhydrinate
Diphenhydramine
Dipping
Electrical measurements
Pharmaceuticals
Sample screening
Screening
Simultaneous determination
Stoichiometry
Strategy
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Summary:Dimenhydrinate (DIM) is a salt composed by the combination of two active pharmaceutical ingredients: diphenhydramine (DIP) and 8‐chlorotheophylline (CTP). In this work, the use of batch injection analysis with multiple pulse amperometric detection (BIA‐MPA) was proposed for the first time for fast stoichiometric determination of DIM. DIP (cation) and CTP (anion) were determined simultaneously in pharmaceutical samples with a simple and fast injection procedure (70 injections h−1). Additional strategies were also proposed for rapid screening of samples containing the DIM salt. By a simple injection of a sample into the BIA system (without using of calibration curve), reliable information about stoichiometry of the DIM salt (1 : 1; DIP:CTP) and presence or absence of interfering species (electroactive) can be achieved.
ISSN:1040-0397
1521-4109
DOI:10.1002/elan.201400300