Fecal lactoferrin and intestinal permeability are effective non-invasive markers in the diagnostic work-up of chronic diarrhea

Non-invasive markers able to identify patients with chronic diarrhea at risk of organic disease are missing. Aim of the study was to assess the diagnostic ability of intestinal permeability (IP) test and fecal lactoferrin (FL) in distinguishing functional from organic disease in patients with chroni...

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Bibliographic Details
Published in:Biometals 2014-10, Vol.27 (5), p.1069-1076
Main Authors: Caccaro, Roberta, D’Incà, Renata, Martinato, Matteo, Pont, Elisabetta Dal, Pathak, Surajit, Frigo, Anna Chiara, Sturniolo, Giacomo Carlo
Format: Article
Language:English
Subjects:
Adult
Alterations
Biochemistry
Biomarkers
Biomarkers - analysis
Biomedical and Life Sciences
Cell Biology
Chronic Disease
Chronic illnesses
Damage
Diagnostic systems
Diagnostic tests
Diarrhea
Diarrhea - diagnosis
Diarrhea - etiology
Diarrhea - metabolism
Feces
Feces - chemistry
Female
Gastrointestinal tract
Humans
Inflammatory Bowel Diseases - complications
Inflammatory Bowel Diseases - diagnosis
Inflammatory Bowel Diseases - metabolism
Intestines - metabolism
Lactoferrin - analysis
Life Sciences
Likelihood ratio
Male
Markers
Medicine/Public Health
Microbiology
Middle Aged
Patients
Permeability
Pharmacology/Toxicology
Plant Physiology
Retrospective Studies
Small intestine
Subgroups
Young Adult
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Summary:Non-invasive markers able to identify patients with chronic diarrhea at risk of organic disease are missing. Aim of the study was to assess the diagnostic ability of intestinal permeability (IP) test and fecal lactoferrin (FL) in distinguishing functional from organic disease in patients with chronic diarrhea. We retrospectively enrolled patients referring to the gastroenterology outpatient clinic for chronic diarrhea. Among the 103 patients included, 40 % had an organic disease, with IP and FL levels significantly higher compared to those with a functional disorder ( p  
ISSN:0966-0844
1572-8773
DOI:10.1007/s10534-014-9745-4