Hydroaminomethylation of Olefins with Aminomethyltrifluoroborate by Photoredox Catalysis

A photocatalytic hydroaminomethylation of olefins with N‐protected aminomethyltrifluoroborates has been developed. This methodology provides a new strategy for the introduction of a primary aminomethyl group onto electron‐deficient CC bonds. This reaction constitutes a facile entry into synthetical...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2014-09, Vol.356 (13), p.2749-2755
Main Authors: Miyazawa, Kazuki, Koike, Takashi, Akita, Munetaka
Format: Article
Language:English
Subjects:
amino acids
aminomethylation
Catalysis
Derivatives
electron transfer
Methodology
Olefins
Photocatalysis
photochemistry
Strategy
Synthesis
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Summary:A photocatalytic hydroaminomethylation of olefins with N‐protected aminomethyltrifluoroborates has been developed. This methodology provides a new strategy for the introduction of a primary aminomethyl group onto electron‐deficient CC bonds. This reaction constitutes a facile entry into synthetically useful γ‐aminobutyric acid (GABA) derivatives such as baclofen.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201400556