Long-Term Effects of Nanoparticles on Nutrition and Metabolism

Nanoparticles have shown great potential in biological and biomedical applications due to their distinct physical and chemical properties. In the meanwhile, the biosafety of nanoparticles has also raised intense concerns worldwide. To address such concerns, great efforts have been made to examine sh...

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Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2014-09, Vol.10 (18), p.3603-3611
Main Authors: Chen, Nan, Wang, Hui, Huang, Qing, Li, Jiang, Yan, Juan, He, Dannong, Fan, Chunhai, Song, Haiyun
Format: Article
Language:English
Subjects:
Animals
autophagy
Biological
Cell Line
Cell Proliferation - drug effects
Cell Survival - drug effects
Cellular
Glucose - metabolism
Gold - chemistry
Health
Homeostasis
Human
Humans
Lipid Metabolism
Lysosomes - metabolism
Metabolic disorders
Metabolic Networks and Pathways
metabolic signaling pathways
Metabolism
Metal Nanoparticles - chemistry
Nanoparticles
Nanotechnology
Nanotechnology - methods
Nutritional Physiological Phenomena
Nutritional Sciences
oxidative stress
Pathways
Signal Transduction - drug effects
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Summary:Nanoparticles have shown great potential in biological and biomedical applications due to their distinct physical and chemical properties. In the meanwhile, the biosafety of nanoparticles has also raised intense concerns worldwide. To address such concerns, great efforts have been made to examine short‐term effects of nanoparticles on cell survival and proliferation. More recently, exploration of long‐term effects of nanomaterials, particularly those with promising biomedical applications in vivo, has aroused significant interest. For example, gold nanoparticles (AuNPs) are generally considered non‐toxic to cell growth, whereas recent studies suggest that AuNPs might have long‐term effects on cellular metabolism and energy homeostasis. In this Review, recent advances in this direction are summarized. Further, possible mechanisms under which nanoparticles regulate metabolic signaling pathways, potential long‐term effects on cellular anabolic or catabolic processes, and their implications in human health and metabolic disorders are discussed. Nanoparticles can interfere with metabolic signaling pathways, which have potential biological consequences on lipid, glucose, and protein homeostasis, and implications in human health and metabolic diseases.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201303635