Core/Shell Au/MnO Nanoparticles Prepared Through Controlled Oxidation of AuMn as an Electrocatalyst for Sensitive H2O2 Detection

• Published in: Angewandte Chemie International Edition 2014-11, Vol.53 (46), p.12508-12512
• Main Authors: Zhu, Huiyuan, Sigdel, Aruna, Zhang, Sen, Su, Dong, Xi, Zheng, Li, Qing, Sun, Shouheng
• Format: Article
• Language: English
• Subjects: Biosensing Techniques; Catalysis; Cell Line, Tumor; Electrochemical Techniques; gold; Gold - chemistry; Humans; hydrogen peroxide; Hydrogen Peroxide - analysis; manganese; Manganese Compounds - chemistry; nanoparticles; Nanoparticles - chemistry; Oxidation-Reduction; Oxides - chemistry; sensors
• ISSN: 1433-7851; 1521-3773
• DOI: 10.1002/anie.201406281

Monodisperse 5 nm AuMn nanoparticles were synthesized by hydride reduction of manganese acetylacetonate in the presence of Au nanoparticles. The alloy was formed through fast Mn diffusion into the Au structure. The AuMn nanoparticles were converted to Au‐MnO composite particles through air annealing at 170 °C. These Au‐MnO particles, especially the core/shell Au/MnO nanoparticles, were active for the electrochemical reduction of H2O2, with a detection limit reaching 8 nM. This highly sensitive electrochemical sensor based on the Au/MnO nanoparticles was used to monitor H2O2 concentrations released from living cells, from which tumorigenic cells were discovered to release higher levels of H2O2 than the non‐tumorigenic cells. Cell sensing: AuMn alloy nanoparticles were synthesized through hydride reduction of manganese acetylacetonate in the presence of Au nanoparticles and were subsequently converted into Au/MnO nanoparticles through air annealing. The Au/MnO nanoparticles are active catalysts for the electrochemical reduction of H2O2 and can be used to measure the H2O2 levels from different types of cells for cancer detection.