EFFECT OF EUPHORBIA CYPARISSIAS OINTMENTS ON ACANTHOSIS

Background: A pharmaco-chemical investigation of the Euphorbia cyparissias plant was justified by its known multiple therapeutic valences. Numerous components from extracts and latex of Euphorbiacae were identified, revealing a large plant family with a polyvalent therapeutic activity. Materials and...

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Bibliographic Details
Published in:African journal of traditional, complementary, and alternative medicines complementary, and alternative medicines, 2014-01, Vol.11 (3), p.1-6
Main Authors: Cristina, Romeo T, Dumitrescu, Eugenia, Brezovan, Diana, Muselin, Florin, Chiurciu, Viorica
Format: Article
Language:English
Subjects:
Acanthosis
Acanthosis Nigricans - drug therapy
Animals
dermatology test
dog
Dogs
Euphorbia - chemistry
Euphorbia cyparissias
Humans
ointments
Ointments - administration & dosage
Plant Extracts - administration & dosage
rat
Rats
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Summary:Background: A pharmaco-chemical investigation of the Euphorbia cyparissias plant was justified by its known multiple therapeutic valences. Numerous components from extracts and latex of Euphorbiacae were identified, revealing a large plant family with a polyvalent therapeutic activity. Materials and Methods: The aim of the study was to assess the skin tolerance level to irritation on different testing concentrations, of Euphorbia cyparissias extracts and ointments. Study was accomplished in rats and dogs, with the identification of all possible skin injuries and histological changes, after a simple patch test methodology. Results: Ointment dermatological testing on rats, proved to be bearable on epilated skin at concentrations of 1, 2 and 5%. Ointments and mother tincture with higher concentrations (10% and 20%), led to irritation and cutis damages, and this was revealed through histology. Conclusion: Ointment tested on dog's skin was tolerable for epilated skin to concentrations of 1, 2 and/or 5%, additional testing on human volunteers confirmed the same situation.
ISSN:0189-6016
2505-0044
0189-6016
DOI:10.4314/ajtcam.v11i3.1