Inhibition of matrix metalloproteinase-1 by dichloromethylene bisphosphonate (clodronate)

Interstitial collagenase present in human jaw cyst extract and purified human fibroblast-type collagenase (MMP-1) were both efficiently inhibited in vitro by clodronate, an osteoactive, antiresorptive bisphosphonate. The IC50 of clodronate to inhibit MMP-1 is 150 microM. These findings suggest an ex...

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Bibliographic Details
Published in:Calcified tissue international 1997-07, Vol.61 (1), p.59-61
Main Authors: Teronen, O, Konttinen, Y T, Lindqvist, C, Salo, T, Ingman, T, Lauhio, A, Ding, Y, Santavirta, S, Valleala, H, Sorsa, T
Format: Article
Language:English
Subjects:
Bone Diseases - drug therapy
Clodronic Acid - therapeutic use
Clodronic Acid - toxicity
Collagen - metabolism
Collagenases - isolation & purification
Collagenases - metabolism
Dose-Response Relationship, Drug
Fibroblasts - enzymology
Humans
Jaw Cysts - enzymology
Matrix Metalloproteinase 1
Matrix Metalloproteinase 8
Matrix Metalloproteinase Inhibitors
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Summary:Interstitial collagenase present in human jaw cyst extract and purified human fibroblast-type collagenase (MMP-1) were both efficiently inhibited in vitro by clodronate, an osteoactive, antiresorptive bisphosphonate. The IC50 of clodronate to inhibit MMP-1 is 150 microM. These findings suggest an extended and hitherto undescribed properties for clodronate/biphosphonates in prevention and treatment of tissue degradation in both bone and soft tissue destructive diseases.
ISSN:0171-967X
1432-0827
DOI:10.1007/s002239900295