Nitrendipine is a potent inhibitor of the Ca super(2+)-activated K super(+) channel of human erythrocytes

Nitrendipine, a classical blocker of L-type Ca super(2+) channels, is shown to be a potent inhibitor of the Ca super(2+)-activated K super(+) channel of human erythrocytes. In erythrocytes suspended in a solution with physiological Na super(+) and K super(+) concentrations and in which the channel w...

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Bibliographic Details
Published in:FEBS letters 1992-01, Vol.296 (2), p.219-221
Main Authors: Ellory, J C, Kirk, K, Culliford, S J, Nash, G B, Stuart, J
Format: Article
Language:English
Subjects:
channels
erythrocytes
inhibition
man
nitrendipine
potassium
Online Access:Get full text
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Summary:Nitrendipine, a classical blocker of L-type Ca super(2+) channels, is shown to be a potent inhibitor of the Ca super(2+)-activated K super(+) channel of human erythrocytes. In erythrocytes suspended in a solution with physiological Na super(+) and K super(+) concentrations and in which the channel was activated using the Ca super(2+) ionophore ionomycin, nitrendipene inhibited K super(+)( super(86)Rb super(+)) influx with an I sub(50) of around 130 nM. Similar results were obtained for K super(+)( super(86)Rb super(+)) efflux, and for K super(+)( super(86)Rb super(+)) influx into cells suspended in a high-K super(+) medium.
ISSN:0014-5793