Exercise tolerance in systemic sclerosis patients without pulmonary impairment: correlation with clinical variables

In systemic sclerosis (SSc) patients pulmonary vasculopathy (PV) is present in the early stage of disease and impairs dilation of affected pulmonary blood vessels, impeding pulmonary blood flow during exercise. Abnormal gas exchange findings were early investigated by cardiopulmonary exercise test (...

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Bibliographic Details
Published in:Clinical and experimental rheumatology 2014-11, Vol.32 (6 Suppl 86), p.S-103-8
Main Authors: Rosato, E, Romaniello, A, Magrì, D, Bonini, M, Sardo, L, Gigante, A, Quarta, S, Digiulio, M A, Viola, G, Di Paolo, M, Jacoangeli, F, Baiocchi, P, Salsano, F, Palange, P
Format: Article
Language:English
Subjects:
Adult
Aged
Case-Control Studies
Exercise Test
Exercise Tolerance - physiology
Female
Forced Expiratory Volume
Hand Dermatoses - etiology
Humans
Hypertension, Pulmonary - etiology
Hypertension, Pulmonary - physiopathology
Lung Diseases - etiology
Lung Diseases - physiopathology
Male
Middle Aged
Oxygen Consumption - physiology
Pulmonary Ventilation - physiology
Scleroderma, Systemic - complications
Scleroderma, Systemic - physiopathology
Skin Ulcer - etiology
Vascular Diseases - etiology
Vascular Diseases - physiopathology
Vital Capacity
Young Adult
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Summary:In systemic sclerosis (SSc) patients pulmonary vasculopathy (PV) is present in the early stage of disease and impairs dilation of affected pulmonary blood vessels, impeding pulmonary blood flow during exercise. Abnormal gas exchange findings were early investigated by cardiopulmonary exercise test (CPET). A total of 34 female and 6 male [median age 49 (20-63) years] SSc patients with normal chest imaging and pulmonary function tests were enrolled. Twenty healthy controls age and sex matched [16 female and 4 male; median age 51 (35-73) years] were also recruited. All subjects underwent a full clinical examination, including a nailfold video capillaros copy (NVC). An incremental symptom-limited CPET was performed with estimation of minute ventilation (VE), workload (WR), peak oxygen uptake (pVO₂2), and ventilatory efficiency (VE/VCO2 slope). A reduced exercise tolerance (pVO₂34). Patients with digital ulcers (DUs) history showed VE/VCO₂slope values significantly higher [31.4 (18-39.6)] than in patients without DUs history [26.9 (22-29.4)] (p
ISSN:0392-856X